Movement disorder specialists’ determination of eligibility for device aided treatment in advanced Parkinson’s disease: Results from the OBSERVE-PD study
Objective: To characterize the clinical and non-clinical features of ‘advanced’ PD patients considered to be eligible or ineligible for device-aided treatment (DAT) options by movement…The occurrence of dopamine-responsive and dopamine-resistant resting tremor in Parkinson’s disease
Objective: To investigate dopamine-responsiveness of resting tremor in Parkinson’s disease Background: Unlike the core Parkinson motor symptom, bradykinesia, resting tremor has a variable response to…A novel paradigm of variable frequency deep brain stimulation to improve freezing of gait in Parkinson’s disease
Objective: To determine the effects of a novel deep brain stimulation (DBS) paradigm of combining high and low frequency stimulation in varying patterns (VFS) for…Evolution in Dopamine Transporter (DaT) Scan Utilization Patterns and its Effect on Treatment Decisions: Results of the Next 200 Scans
Objective: To describe further changes in DaT scan utilization and its influence on management following our initial experience. Background: We previously reported our DaT scan…Metabolic changes following transcranial magnetic resonance-guided focused ultrasound subthalamotomy
Objective: As part of a pioneer trial to investigate the use of transcranial magnetic resonance-guided focused ultrasound subthalamotomy (MRgFUS-STN) in Parkinson's disease (PD), this study addresses…Speech difficulties are linked to striatal dopaminergic deficits and cognitive decline in early de novo patients with Parkinson’s disease
Objective: To investigate whether speech difficulties are associated with striatal dopaminergic deficits and whether are linked to progression of symptoms in early de novo patients…Decreased Fronto-Parietal connection is associated with face pareidolia in Parkinson’s disease.
Objective: To investigate the neural mechanism of face pareidolia in Parkinson’s disease (PD) patients using resting state functional magnetic resonance imaging (rs-fMRI). Background: Face pareidolia…Dopamine depletion impairs gait automaticity by altering cortico-striatal and cerebellar processing in Parkinson’s disease
Objective: Investigating the role of dopaminergic medication on the neural mechanisms underlying lower limb motor automaticity during fMRI in 23 patients with PD that were…The role of phosphodiesterase 4 in sleep disturbances in Parkinson’s disease
Objective: We aimed to assess the association between phosphodiesterase 4 (PDE4) expression and sleep disturbances in vivo using combined multimodal magnetic resonance imaging (MRI) and…Clinical utility of visualization of Nigrosome-1 in patients with Parkinson’s disease
Objective: To determine the inter-rater reliability of Nigrosome-1 detection and its relation to asymmetry of clinical symptoms in Parkinson’s disease (PD). Background: Detection of Nigrosome-1…
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