An unusual presentation of tyrosine hydroxylase deficiency
Objective: To discuss a case of tyrosine hydroxylase deficiency presenting with resolution of symptoms on levodopa except for a dynamic segmental dystonia Background: Dopa-responsive dystonia…Abnormal activity in reward system in Parkinson’s disease patients with rapid eye movement sleep behavior disorder
Objective: To study the mesocorticolimbic reward system in Parkinson's disease (PD) patients with and without REM sleep behavior disorder (RBD). Background: RBD is a parasomnia…The Personal Kinetigraph Fluctuator Score Identifies Motor Fluctuations in Parkinson’s disease
Objective: To evaluate the Personal Kinetigraph (PKG) fluctuator score (FS) in detecting motor fluctuations in Parkinson's disease (PD) patients. Background: Fluctuations of response to levodopa,…Patient Clustering through a Mobile-based PD Severity Score
Objective: To demonstrate that PD patients can be clustered based on their performance on smartphone-enabled active tests. Background: Treatment decisions of PD require granular information…Istradefylline improves motor symptoms in Parkinson’s disease: A meta-analysis
Objective: The aim of this meta-analysis was to provide strong evidence for the main and side effects of istradefylline on patients with Parkinson’s disease. Background:…Targeting alpha-Synuclein Aggregation for the Treatment of Parkinson’s Disease
Objective: To develop small molecular weight compounds (SMEs) as disease-modifying agents, which are designed to arrest or even reverse the aggregation process of alpha-synuclein (aSyn)…Intranasal delivery of insulin for the restoration of memory signaling in Alzheimer disease
Objective: Objective of this study is to develop delivery-system to overcome BBB by employing novel, non-invasive approach via nasal route. The olfactory neural pathway provides…Gray Matter Density in Essential Tremor: A Lobule by Lobule Analysis of the Cerebellum
Objective: Our hypothesis was that regional differences in cerebellar gray matter (GM) density may better distinguish essential tremor (ET) cases from controls. Background: The pathophysiological…Tremor in motorneuron disease: central or peripheral origin?
Objective: To investigate whether postural/action tremor in motorneuron disease (MND) has a central origin. Background: MND refers to the whole spectrum of progressive degenerative diseases…Effect of Virtual Reality on Balance Rehabilitation
Objective: To verify the effect of a balance rehabilitation program with virtual reality (VR) in patients with SCA Background: Spinocerebellar ataxias (SCAs) constitute a group…
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