Effects of TRH therapy on the prism adaptation task in patients with spinocerebellar degeneration.
Objective: To reveal effects of TRH therapy on the prism adaptation task in patients with spinocerebellar degeneration (SCD). Background: TRH [Thyrotropin releasing hormone (protirelin tartrate)]…The Impact of Cognitive Changes on Everyday Life for People with Parkinson’s: The Patient’s Perspective
Objective: To understand the patient’s perspective about cognitive changes in Parkinson’s disease and about the impact of cognitive dysfunction on daily life. Background: Cognitive dysfunction is…Quantifying reinforcement learning deficits in early stage Parkinson’s patients using a strategic decision-making task
Objective: 1.Characterize deficits in reinforcement learning processes in PD during a strategic game analogous to Rock-Paper-Scissors (RPS). 2.Examine the effects of dopaminergic (DA) treatment on…Action Verbal Fluency is Related to the Functional Integrity of the Cognitive Cortico-Striatal Loop in Parkinson’s Disease
Objective: The objective of this study is to investigate the relationship between action verbal fluency (the capacity to name as many action words as possible…Oscillatory dynamics of impaired novelty detection at early Parkinson’s disease
Objective: In this work we aimed to describe the brain oscillations associated with impaired novelty detection at early PD. Background: Cognitive impairment, especially attentional and…Understanding the role of LRRK2 in Indian population
Objective: Genomic approaches in Caucasian population show little transferability to other ethnically diverse populations such as Indian population. Understanding the genetic architecture of a disease…Mitochondrial DNA variants function as potential genetic risk factors for Parkinson disease
Objective: To understand whether mtDNA variants contribute to the susceptibility to sporadic PD. Background: It is well-recognized that mitochondrial (mt) dysfunction is involved in the…Genetic, epigenetic and expression profiles in alpha-synucleinopathies
Objective: To determine whether each of the alpha-synucleinopathies has distinct methylation and/or expression profiles that distinguishes them from other disorders in this class. Background: The…Gene associated differences in pre-diagnostic symptoms of Parkinson’s Disease: a retrospective study
Objective: To investigate whether glucocerebrosidase (GBA) L444P and leucine-rich repeat kinase 2 (LRRK2) G2385R and R1628P mutations are associated with different symptoms and manifesting patterns…Treatment of Parkinson’s disease psychosis–a systematic review of RCTs
Objective: An SLR was conducted to assess the evidence from RCTs supporting the safety and efficacy of Parkinson’s disease psychosis (PDP) treatments. Background: PDP is…
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