A Double-Blind, Randomized, Placebo-Controlled, Cross-Over Phase IIa Trial to Evaluate the Efficacy of CVXL-0107 on Parkinson-Related Symptoms and Levodopa-Induced Dyskinesia in Advanced Parkinson’s Disease
Objective: To evaluate the efficacy of CVXL-0107 on motor symptoms and on levodopa-induced dyskinesia in advanced Parkinson’s disease (PD) patients. Background: CVXL-0107 is a glutamate…PLG restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models
Objective: Parkinson disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease and there are few treatments currently available. The present study investigated…Rationale and Design of an Open-Label, Randomized, 26-Week Study Comparing Levodopa-Carbidopa Intestinal Gel to Optimized Medical Treatment on Non-Motor Symptoms in Patients with Advanced Parkinson’s Disease – INSIGHTS Study
Objective: To examine levodopa-carbidopa intestinal gel, LCIG (also known as carbidopa-levodopa enteral suspension in the US), on non-motor symptoms (NMS) compared with individually-optimized, conventional PD…Relationship between CTG repeats, Muscle Weakness and Respiratory Dysfunction in Myotonic Dystrophy Type 1
Objective: This study aims to assess the association between CTG repeats, muscle weakness and respiratory dysfunction in a cohort of individuals with myotonic dystrophy type…VIT-D and Tics Movement Disorder
Objective: Tics is common childhood movement disorder, with classified variants , typically begin at around 4-5 years of age but often present later at about…High dose of levodopa and Segawa disease
Objective: To analyze the dose-dependent effects of levodopa on the symptoms of the disease in our case. Background: In 1976, Segawa et al. reported dopa-responsive…From Non-rechargeable to Rechargeable Technology: Insights and Management of Pallidal Deep Brain Stimulation in Dystonia after Switching to a Rechargeable Implantable Pulse Generator
Objective: Here, we aimed to evaluate the management of stimulation intensities after switching from NRC to RC IPG compared to previous RC-to-RC replacements. Background: Patients…The effectiveness of deep brain stimulation in dystonia: A patient-centered approach
Objective: To systematically evaluate the effectiveness of deep brain stimulation of the Globus Pallidus internus (GPi-DBS) in dystonia on pre-operatively set functional priorities in daily…Weight loss in STN DBS in Parkinson’s Disease? Long-term outcome of a prospective cohort at 5 years
Objective: To determine the long-term weight changes in Parkinson’s Disease (PD) after Subthalamic Nucleus (STN) Deep Brain Stimulation (DBS) treatment. Background: It is well-established that…Directional deep brain stimulation in Parkinson’s disease guided by local field potentials
Objective: Implementation of directional stimulation of subthalamic nucleus with segmented leads guided by local field potential (LFP) recordings in order to personalize DBS parameters, optimize…
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