PLG restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models
Objective: Parkinson disease (PD) is the second most common neurodegenerative disorder after Alzheimer disease and there are few treatments currently available. The present study investigated…Rationale and Design of an Open-Label, Randomized, 26-Week Study Comparing Levodopa-Carbidopa Intestinal Gel to Optimized Medical Treatment on Non-Motor Symptoms in Patients with Advanced Parkinson’s Disease – INSIGHTS Study
Objective: To examine levodopa-carbidopa intestinal gel, LCIG (also known as carbidopa-levodopa enteral suspension in the US), on non-motor symptoms (NMS) compared with individually-optimized, conventional PD…Relationship between CTG repeats, Muscle Weakness and Respiratory Dysfunction in Myotonic Dystrophy Type 1
Objective: This study aims to assess the association between CTG repeats, muscle weakness and respiratory dysfunction in a cohort of individuals with myotonic dystrophy type…VIT-D and Tics Movement Disorder
Objective: Tics is common childhood movement disorder, with classified variants , typically begin at around 4-5 years of age but often present later at about…High dose of levodopa and Segawa disease
Objective: To analyze the dose-dependent effects of levodopa on the symptoms of the disease in our case. Background: In 1976, Segawa et al. reported dopa-responsive…From Non-rechargeable to Rechargeable Technology: Insights and Management of Pallidal Deep Brain Stimulation in Dystonia after Switching to a Rechargeable Implantable Pulse Generator
Objective: Here, we aimed to evaluate the management of stimulation intensities after switching from NRC to RC IPG compared to previous RC-to-RC replacements. Background: Patients…The effectiveness of deep brain stimulation in dystonia: A patient-centered approach
Objective: To systematically evaluate the effectiveness of deep brain stimulation of the Globus Pallidus internus (GPi-DBS) in dystonia on pre-operatively set functional priorities in daily…Weight loss in STN DBS in Parkinson’s Disease? Long-term outcome of a prospective cohort at 5 years
Objective: To determine the long-term weight changes in Parkinson’s Disease (PD) after Subthalamic Nucleus (STN) Deep Brain Stimulation (DBS) treatment. Background: It is well-established that…Directional deep brain stimulation in Parkinson’s disease guided by local field potentials
Objective: Implementation of directional stimulation of subthalamic nucleus with segmented leads guided by local field potential (LFP) recordings in order to personalize DBS parameters, optimize…Evaluation of apathy before and after subthalamic nucleus deep brain stimulation therapy in advanced Parkinson’s disease patients
Objective: Deep brain stimulation (DBS) has been approved to relieve the motor symptoms of Parkinson's disease (PD) patients when the optimal pharmachologic treatment is unsatisfactory.…
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