Pallidal and thalamic oscillations are associated with tic severity in patients with Tourette syndrome
Objective: The present study aimed at elucidating the pathophysiological role of pallidal and thalamic oscillatory local field potential (LFP) dynamics in patients with Tourette Syndrome.…Novel mechanistic involved in targeting Parkinsons Disease by Indolocarbazole derivatives as inhibitors against Cyclin Dependent kinases using molecular modelling and simulation approaches
Objective: To validate effect of Indolocarbazole derivatives on Cyclin dependent kinase for treating Parkinson's (Preliminary work in context of CDK5 assay and Simulations have been…GASTROPARK: Multicenter study on the efficacy of dopamine agonists for gastrointestinal symptoms in Parkinson’s disease
Objective: Main: To assess the modification of gastrointestinal symptoms in patients with Parkinson's disease before and after the introduction of dopamine agonists. Secondary: (1) To…Outcomes of a Prospective, Multi-center International Registry of Deep Brain Stimulation for Parkinson’s Disease
Objective: The objective this report is to describe collected outcomes from a large scale registry of a Deep Brain Stimulation (DBS) system capable of Multiple…Effects of non-invasive brain stimulation on motor-speech disorders in Parkinson’s disease
Objective: To investigate acute effects of repetitive transcranial magnetic stimulation (rTMS) of the motor and auditory feedback area on hypokinetic dysarthria in Parkinson’s disease (PD)…Liquid sinemet in the management of complex motor fluctuations in advanced Parkinson’s Disease
Objective: To investigate the effectiveness of Levodopa carbidopa ascorbic acid solution (LCAS) in reducing the severity of bradykinesia and dyskinesia in advanced Parkinson’s disease (PD).…Occurrence of dopaminergic adverse-events in COMT-naïve patients starting adjunctive therapy with opicapone: The BIPARK-I double-blind experience
Objective: To assess the occurrence of dopaminergic adverse-events (AEs) in levodopa-treated COMT-naïve Parkinson’s Disease (PD) patients when starting opicapone (OPC) 50mg or entacapone (ENT). Background:…DIRECT DBS: A Prospective, Multicenter Clinical Study with Double-Blinding for a Directional Deep Brain Stimulation Lead – Therapeutic Windows with Directional Stimulation
Objective: To evaluate changes in therapeutic window values for changes in directional Deep Brain Stimulation (DBS) stimulation. Background: Historically, DBS systems have delivered stimulation using…Neurorestorative effects of glycine transporter 1-inhibitor and D-Serine in a mouse model of nigrostriatal dopaminergic degeneration
Objective: We set out to evaluate potential neurorestorative effects of the GlyT1 inhibitor ACPPB vis-à-vis D-Serine in the intrastriatal 6-OHDA mouse model of Parkinson’s disease.…The NIC-PD-study –A randomized, placebo-controlled, double-blind, multi-centre trial to assess the disease-modifying potential of transdermal nicotine in early Parkinson‘s disease in Germany and N. America
Objective: To evaluate the disease modifying potential of transdermal (TD) nicotine in early Parkinson’s disease (PD). For this explanatory purpose, the primary endpoint was the…
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