Neurorestorative effects of glycine transporter 1-inhibitor and D-Serine in a mouse model of nigrostriatal dopaminergic degeneration
Objective: We set out to evaluate potential neurorestorative effects of the GlyT1 inhibitor ACPPB vis-à-vis D-Serine in the intrastriatal 6-OHDA mouse model of Parkinson’s disease.…The NIC-PD-study –A randomized, placebo-controlled, double-blind, multi-centre trial to assess the disease-modifying potential of transdermal nicotine in early Parkinson‘s disease in Germany and N. America
Objective: To evaluate the disease modifying potential of transdermal (TD) nicotine in early Parkinson’s disease (PD). For this explanatory purpose, the primary endpoint was the…Individualization of levodopa treatment using a microtablet dispenser and ambulatory accelerometry
Objective: This four-week open-label observational study describes the effect of introducing a microtablet dose dispenser and adjusting doses based on objective free-living motor symptom monitoring…Impulse control disorders could be accompanied by hypomanic state under intestinal levodopa infusion
Objective: To determine characteristics of parkinsonian patients under levodopa/carbidopa intestinal gel (LCIG) infusion who present impulse control disorders (ICDs). Background: ICDs may be induced by…Speech Intelligibility in Parkinson’s disease following Intensive Voice and Articulation Treatments
Objective: Our aim was to evaluate the impact of voice treatment (LSVT LOUD) and articulation treatment (LSVT ARTIC) on speech and consonant intelligibility in Parkinson's…Double-blind controlled trial of Spectramax™ light therapy for the treatment of Parkinson’s disease patients on stable dopaminergic therapy
Objective: To evaluate the safety and effectiveness of Spectramax™ specialized bandwidth light therapy (LT) as adjunctive treatment in Parkinson’s disease (PD). Background: Previous studies have…Deep brain stimulation matters in pediatric neurology – single-center experience
Objective: This study is to review our single-center experience with deep brain stimulation (DBS) in pediatric patients with dystonia. Background: Deep brain stimulation (DBS) is…Movement disorder associated with 3-Idroxyisobutyryl-Coa hydrolase (HIBCH) deficiency
Objective: To describe an early onset movement disorder due to impairment of valine metabolism. Background: HIBCH deficiency is a rare inborn error of valine metabolism…Neurologic Wilson’s Disease: Case Series on a Diagnostic and Therapeutic Emergency
Objective: To present two cases of Neurologic Wilson's Disease with two different clinical picture. To review the the important diagnostics and tests in clinching the…MRI-guided Focused Ultrasound thalamotomy for Multiple Sclerosis-associated tremor: A case report
Objective: To describe the effect of VIM thalamotomy by MRI-guided Focused Ultrasound (MRIgFUS) on Multiple Sclerosis (MS) tremor in a single patient. Background: Tremor is…
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