Effect of PD medication on disease progression as measured by rate of change in MDS_UPDRS and DaT SBR in PPMI study
Objective: In clinical trials for new PD therapies, it is common for patients to start to take approved symptomatic PD medications during the study. The…Efficacy of zonisamide on motor symptoms in dementia with Lewy bodies: A post-hoc analysis of a phase 3 study
Objective: To characterize the efficacy of zonisamide in improving motor symptoms, we performed a post-hoc analysis using data from a phase 3 study that evaluated…Proof-of-Principle Quantitative EEG Study of CX-8998, an Oral, Potent and Selective T-Type Calcium antagonist in development for symptomatic treatment of Essential Tremor and Parkinson’s disease Tremor
Objective: To study the pharmacodynamics (PD) of CX-8998, using pharmaco-electroencephalography (phEEG) and define plasma concentrations of CX-8998 which are pharmacologically active on objective CNS parameters.…Motor and non-motor correlates of APOE-ε4 mediated cerebrospinal fluid concentrations of biomarkers of amyloidogenesis and neurodegeneration in dementia with Lewy bodies compared with Alzheimer’s dementia and healthy controls
Objective: To study associations of cerebrospinal fluid biomarkers of amyloidogenesis and neurodegeneration with motor and non-motor aspects of daily experiences in dementia with Lewy bodies…Molecular immunological action and epigenetic modification of the human papillomavirus vaccination and associated neuropsychiatric side effects
Objective: To investigate the clinical manifestations of neuropsychiatric side effects after the Human papillomavirus (HPV) vaccine, and to investigate the immunological actions and epigenetic modification.…Using tablet devices to educate patients about dystonia and botulinum toxin for movement disorders
Objective: To assess the efficacy of tablet-based learning modules for patient education in an outpatient movement disorders center. Background: Educational materials improve patient understanding, and…Evaluating the Knowledge, Practice and Experience about Management of Parkinson’s Disease among Physiotherapists in Ghana: A Cross sectional Survey
Objective: To identify the level of Parkinson's disease (PD)-specific knowledge about the clinical manifestations, evidence-based practice, skills and experience in the management of PD among…Autosomal dominant PANK2 mutation resulting in cervical dystonia with iron accumulation in the basal ganglia
Objective: Identification and functional analysis of the disease-causing gene in a family with dominantly inherited cervical dystonia. Background: With the introduction of next generation sequencing…Comparison of clinical characteristics and treatment outcomes of botulinum neurotoxin in routine clinical practice between hemifacial spasm with and without the Babinski-2 sign in Thai patients: An exploratory study
Objective: To compare the clinical characteristics, along with the treatment outcomes of botulinum neurotoxin (BoNT) between HFS patients with and without the BBK-2 sign as…Identifying therapeutic targets from spontaneous beneficial brain lesions
Objective: To determine whether rare cases in which spontaneously occurring brain lesions improved tremor can be used to identify a therapeutic target. Background: The search…
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