Closed Loop Programming Evaluation Using External Responses for Deep Brain Stimulation (CLOVER-DBS)
Objective: To assess the feasibility and efficacy of a novel closed-loop programming algorithm (CLPA) for deep brain stimulation (DBS) based on objective feedback using a…It takes two to tango but following may be more beneficial for rehabilitating people with mild-moderate Parkinson’s
Objective: This study determined the efficacy of internally guided (leading) versus externally guided (following) in adapted tango versus a contact-matched control group (wellness education) for…Oral treatment with sphingosine-1-phosphate receptors modulator prevents Parkinson symptoms concomitantly to reduced brain inflammation in MPTP mouse models
Objective: Here we explore the efficacy of an oral treatment with Fingolimod (FTY720), a selective sphingosine-1-phosphate receptors modulator, to prevent MPTP induced nigrostriatal loss and…Acute efficacy and tolerability of the COMT inhibitor opicapone
Objective: Evaluation of the acute efficacy and tolerability of Opicapone. Background: Opicapone is a Catechol-O-Methyltransferase (COMT) inhibitor for the treatment of patients with idiopathic Parkinson’s…Characteristics of dopaminergic treatments in advanced Parkinson’s before levodopa-carbidopa intestinal gel infusion: Data from 107 tested patients
Objective: To describe the characteristics of dopaminergic treatments in a large group of patients with advanced Parkinson’s Disease (APD) in which current non-invasive therapy (oral,…Effects of Expiratory Muscle Strength Training and Voice Therapy on Parkinsonian Speech
Objective: The current study compared the effects of expiratory muscle strength training (EMST) and EMST plus voice therapy (VT) on speech loudness and intelligibility of…A novel non-nitrocatechol COMT inhibitor ODM-104 shows superior pharmacodynamic effects to entacapone
Objective: ODM-104 is a novel non-nitrocatechol catechol-O-methyltransferase (COMT) inhibitor that is undergoing clinical evaluation for Parkinson’s disease (PD). This study investigated the pharmacodynamic effects of…Multimodal evoked potential analysis in Woodhouse-Sakati Syndrome
Objective: Investigate Woodhouse-Sakati syndrome through analysis of multimodal evoked potentials at various clinical stages, to assess their possible role as an aid in determining the…Movement disorder masquerading as seizure disorder
Objective: The main objective of presenting this case report is to emphasise the importance of accurate clinical diagnosis of movement disorder in children which many…Juvenile parkinsonism associated with a novel HSD17B10 mutation in a patient with HSD10 disease
Objective: We describe the case of a female patient with HSD10 disease associated with parkinsonism, with a novel mutation in the HSD17B10 gene. Background: HSD10…
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