Oral treatment with JNX3001 protects dopaminergic function in a non-human primate model of Parkinson’s disease alpha-synucleinopathy
Objective: We evaluated the efficacy of JNX3001 in an aSyn-based macaque model with plasma exposures associated with efficacy in rodents. Background: Alpha-synuclein (aSyn) deposition is…Reduction of neuroinflammation by selective inhibition of the N-type calcium channel is beneficial in various animal models of neurodegeneration, here in the SOD1G93A transgenic mouse model of ALS
Objective: Neuroinflammation is a pathological hallmark of several neurodegenerative diseases. We speculated that reduction of calcium ion influx specifically in neurons should reduce inflammatory cellular…Rose Anthocyanins protect against Parkinson’s pathophysiology: Behavioral and biochemical changes in young Drosophila
Objective: To test the hypothesis that Rose Anthocyanins, owing to their biological properties in vitro, protect against Parkinson’s pathophysiology in young Drosophila melanogaster. Background: Anthocyanins…Oligosymptomatic Fahr’s syndrome (2 clinical cases)
Objective: Two clinical cases of Fahr`s syndrome was presented. Background: Fahr's syndrome (FS) or secondary bilateral striatopallidodentate calcinosis is a rare neurological disorder characterized by…Improvement in chorea and function in a patient with dystonia-choreoathetosis cerebral palsy after treatment with bilateral pallidal deep brain stimulation
Objective: We describe and demonstrate by video a patient with dystonia-choreoathetosis cerebral palsy treated with bilateral pallidal deep brain stimulation (DBS). Background: Dystonia-choreoathetosis cerebral palsy…Long-term habituation of deep brain stimulation for essential tremor: An observer-blinded study
Objective: Deep brain stimulation (DBS) of the thalamic ventrointermedius nucleus (Vim) is an accepted treatment for severe, drug-resistant essential tremor. There is an ongoing debate…Impact of Subthalamic Nucleus Stimulation on Striatal Dopamine Transporter in Parkinsonian Rat Models
Objective: To investigate the impact of subthalamic nucleus deep brain stimulation (STN-DBS) on striatal dopamine transporter (DAT) of Parkinsonian rat models. Background: STN-DBS has become…A Patient-Centered Decision-Making Algorithm for Deep Brain Stimulation Surgery in Parkinson’s Disease
Objective: To develop a computer application with responsive design to incorporate Parkinson’s Disease (PD) patients’ expectations for Deep Brain Stimulation (DBS) surgery and present them…Spontaneous peri-electrode edema, 7 years after subthalamic nucleus deep brain stimulation (STN-DBS) in a patient with Parkinson´s disease (PD): A case report
Objective: To describe an infrequent and late complication of STN-DBS in a patient with PD. Background: DBS is a safe procedure for patients with PD.…The efficacy and safety of STN-DBS under general anesthesia for PD patients
Objective: This study was a comparative studies of the efficacy of bilateral subthalamic deep brain stimulation (STN-DBS) for Parkinson’s disease (PD) under general anesthesia (GA)…
- « Previous Page
- 1
- …
- 145
- 146
- 147
- 148
- 149
- …
- 177
- Next Page »