MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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  • 2018 International Congress

    Oral treatment with JNX3001 protects dopaminergic function in a non-human primate model of Parkinson’s disease alpha-synucleinopathy

    P. Howson, T. Johnston, J. Brotchie, M. Hill, J. Koprich (Toronto, ON, Canada)

    Objective: We evaluated the efficacy of JNX3001 in an aSyn-based macaque model with plasma exposures associated with efficacy in rodents. Background: Alpha-synuclein (aSyn) deposition is…
  • 2018 International Congress

    Reduction of neuroinflammation by selective inhibition of the N-type calcium channel is beneficial in various animal models of neurodegeneration, here in the SOD1G93A transgenic mouse model of ALS

    J. Post-Schulz, A. Willuweit, V. Kogel, K. Langen, J. Kutzsche, D. Willbold (Jülich, Germany)

    Objective: Neuroinflammation is a pathological hallmark of several neurodegenerative diseases. We speculated that reduction of calcium ion influx specifically in neurons should reduce inflammatory cellular…
  • 2018 International Congress

    Rose Anthocyanins protect against Parkinson’s pathophysiology: Behavioral and biochemical changes in young Drosophila

    G. Chandran, P. Chandrashekar, M. Jayaraju, J. Chauhan (Mysuru, India)

    Objective: To test the hypothesis that Rose Anthocyanins, owing to their biological properties in vitro, protect against Parkinson’s pathophysiology in young Drosophila melanogaster. Background: Anthocyanins…
  • 2018 International Congress

    Oligosymptomatic Fahr’s syndrome (2 clinical cases)

    Y. Solodovnikova (Odessa, Ukraine)

    Objective: Two clinical cases of Fahr`s syndrome was presented. Background: Fahr's syndrome (FS) or secondary bilateral striatopallidodentate calcinosis is a rare neurological disorder characterized by…
  • 2018 International Congress

    Improvement in chorea and function in a patient with dystonia-choreoathetosis cerebral palsy after treatment with bilateral pallidal deep brain stimulation

    Y. Fernandez, B. Kopell, W. Tse (New York, NY, USA)

    Objective: We describe and demonstrate by video a patient with dystonia-choreoathetosis cerebral palsy treated with bilateral pallidal deep brain stimulation (DBS). Background: Dystonia-choreoathetosis cerebral palsy…
  • 2018 International Congress

    Long-term habituation of deep brain stimulation for essential tremor: An observer-blinded study

    S. Paschen, J. Forstenpointner, J. Becktepe, H. Hellriegel, K. Witt, AK. Helmers, G. Deuschl (Kiel, Germany)

    Objective: Deep brain stimulation (DBS) of the thalamic ventrointermedius nucleus (Vim) is an accepted treatment for severe, drug-resistant essential tremor. There is an ongoing debate…
  • 2018 International Congress

    Impact of Subthalamic Nucleus Stimulation on Striatal Dopamine Transporter in Parkinsonian Rat Models

    W. Xian, Q. Guo, L. Jiang, Z. Pei, L. Chen (Guangzhou, China)

    Objective: To investigate the impact of subthalamic nucleus deep brain stimulation (STN-DBS) on striatal dopamine transporter (DAT) of Parkinsonian rat models. Background: STN-DBS has become…
  • 2018 International Congress

    A Patient-Centered Decision-Making Algorithm for Deep Brain Stimulation Surgery in Parkinson’s Disease

    S. Joza, K. Yen, F. Ba, J. Miyasaki (Edmonton, AB, Canada)

    Objective: To develop a computer application with responsive design to incorporate Parkinson’s Disease (PD) patients’ expectations for Deep Brain Stimulation (DBS) surgery and present them…
  • 2018 International Congress

    Spontaneous peri-electrode edema, 7 years after subthalamic nucleus deep brain stimulation (STN-DBS) in a patient with Parkinson´s disease (PD): A case report

    O. Morsi, J. Lopez, J. Jimenez, L. Fuentes, G. Valero, A.E. Baidez, E. Andreu (Murcia, Spain)

    Objective: To describe an infrequent and late complication of STN-DBS in a patient with PD. Background: DBS is a safe procedure for patients with PD.…
  • 2018 International Congress

    The efficacy and safety of STN-DBS under general anesthesia for PD patients

    W. Chen, L. Chen (Guangzhou, China)

    Objective: This study was a comparative studies of the efficacy of bilateral subthalamic deep brain stimulation (STN-DBS) for Parkinson’s disease (PD) under general anesthesia (GA)…
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