Design of a Phase 3 Efficacy and Safety Trial of Accordion Pill™ Carbidopa/Levodopa for Parkinson’s Disease (PD) Patients Experiencing Motor Fluctuations
Objective: To review the design and unique features of an ongoing phase 3 trial of a gastric-retentive formulation of carbidopa/levodopa (CD/LD), the Accordion Pill™ (AP),…Does motor laterality affect the development of dyskinesia in patients with Parkinson’s disease?
Objective: To investigate the effects of motor laterality on the development of levodopa-induced dyskinesia (LID) in patients with de novo Parkinson’s disease (PD). Background: LID…Levodopa induced dyskinesia is preventable (15 years experience using continuous dopaminergic stimulation)
Objective: To evaluate whether levodopa induced dyskinesia is preventable in the treatment of patients with Parkinson’s disease. Background: Dyskinesia is one of the major complications…Magnetic resonance imaging-guided focused ultrasound unilateral pallidotomy for Parkinson’s disease: A report of 2 patients
Objective: To present two patients of Parkinson’s disease (PD) with Magnetic resonance imaging-guided focused ultrasound (MRgFUS) unilateral pallidotomy. Background: MRgFUS is a new technology that…Highly-selective blockade of 5-HT2A receptors with EMD-281,014 reduces the severity of L-DOPA-induced psychosis and dyskinesia in the MPTP-lesioned marmoset model of Parkinson’s disease
Objective: To investigate the effect of the highly-selective serotonin 2A (5-HT2A) receptor EMD-281,014 on L-3,4-dihydroxyphenylalanine (L-DOPA)-induced psychosis-like behaviours (PLBs) and dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.