Cohort profile of the Japan Dystonia Consortium: Genetic diagnosis and characteristics of movement disorders in Japan
Objective: To reveal molecular epidemiology of hereditary dystonia through resequencing of the currently-known dystonia genes and identification of novel genetic defects. Background: The Japan Dystonia…Prevelance in the World
Objective: To analyze the static data in the incidence of Parkinson disease in the world. Background: Parkinson’s disease is considered a progressive multisystem disorder involving…A randomized, double-blind, placebo-controlled Phase II Efficacy and Safety Study of the PDE10A inhibitor PF-02545920 in Huntington Disease (AMARYLLIS)
Objective: To assess efficacy on motor function, safety and tolerability of the phosphodiesterase-10A inhibitor PF-02545920 in Huntington disease (HD). Conclusion: PF-02545920 was generally safe and…Neuroprotective role of cinnamaldehyde against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington’s disease
Objective: The present study examined the potential therapeutic effects of CA against 3-nitropropionic acid (3-NP)-induced oxidative stress in a rat model of HD and explored…Motor and Non-motor Features Predict Freezing of Gait in Parkinson’s Disease
Objective: To investigate and evaluate behavioral predictors of conversion to Freezing of Gait in Parkinson’s Disease (PD). Background: Freezing of Gait (FOG) has devastating consequences…
