Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors
Objective: In this study we aim to elucidate the role of Kif5b motor subunit in the nigrostriatal pathway. We have generated different conditional knockout mice…Genetic variations of SNCA and striatal dopaminergic dysfunction in patients with Parkinson’s disease
Objective: The aim of the present study was to investigate genetic variants in SNCA associated with accelerated deterioration in striatal dopaminergic activity. Background: Widespread a-synuclein…A pilot study of plasma ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) as a potential blood-based biomarker in Parkinson’s disease
Objective: To determine plasma levels of UCH-L1 in patients with PD, and to investigate the association with both genetic (leucine-rich repeat kinase 2, LRRK2 and…Longitudinal changes in Neuromelanin MRI Signal in Parkinson’s Disease
Objective: To examine the longitudinal changes in neuromelanin (NM) MRI signal in the substantia nigra (SN) in Parkinson’s disease (PD). Background: PD is characterized by…Transcranial imaging of substantia nigra hyperechogenicity in a Chinese cohort of Parkinson’s disease
Objective: In this research we set out to study the diagnostic value of TCS in Parkinson's disease. Background: An increased echogenicity of the substantia nigra…Improvement of antisaccade amplitude by the STN DBS and target eccentricity
Objective: To investigate the dependency of antisaccade (AS) amplitude improvement by the subthalamic nucleus (STN) deep brain stimulation (DBS) on the target eccentricity in Parkinson’s…The usefulness of 18 F-DOPA PET scan in diagnostically challenging patients at a movement disorder clinic
Objective: The aim of this study was to determine the usefulness of 18 F-DOPA PET scan in diagnostically challenging patients at our movement disorder clinic…Changes in cortical thickness in patients with early Parkinson’s disease at different Hoehn and Yahr stages
Objective: This study was designed to explore changes in cortical thickness in patients with early Parkinson's disease (PD) at different Hoehn and Yahr (H-Y) stages…The effect of age on Substantia Nigra Hyperechogenicity in PD patients and healthy controls
Objective: To analyze whether the size of SN+ is differentially affected depending on disease start side. Secondly to analyze the interaction between a range of…Alteration to Basal Ganglia Morphology in Freezing of Gait in Parkinson’s Disease
Objective: To characterize the subcortical grey matter adaptations related to Freezing of Gait in Parkinson’s Disease (PD). Background: Owing to its connections with motor, cognitive…
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