Chitotriosidase is a biomarker for Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP)
Objective: ALSP belongs to the large group of rare neurogenetic, adult-onset leukodystrophies. For most of these leukodystrophies, including ALSP, no causative treatment exists. Biomarkers facilitate…Deep brain stimulation: A Treatment Modality for Generalized Dystonia Secondary to Anoxic Brain Injury in Adults
Objective: To report a case of severe generalized dystonia secondary to anoxic brain injury treated successfully with bilateral globus pallidus interna (GPi) deep brain stimulation…Predictor for speech deterioration following STN-DBS in PD patients
Objective: We conducted a 2-year prospective study of PD patients treated with subthalamic nucleus deep brain stimulation (STN-DBS) to elucidate the predictive factors of deterioration…Subthalamic neuromodulation restores motor learning in Parkinson’s disease
Objective: The aims of the present study were to (i) investigate the effect of subthalamic deep brain stimulation (STN-DBS) on motor learning in Parkinson’s disease…Attitudes toward earlier use of deep brain stimulation among patients with Parkinson’s disease
Objective: To explore Parkinson’s patient experiences with Deep Brain Stimulation (DBS) and attitudes towards earlier use of DBS. Background: In November 2015 the U.S. Food…The effects of deep brain stimulation of the pedunculopontine nucleus on cognition in Parkinson’s disease and Progressive Supranuclear Palsy
Objective: To investigate the effects of deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) on different cognitive domains for Parkinson’s disease (PD) and progressive…Impact of STN-DBS on Medication Reduction
Objective: We aim to evaluate the efficacy of subthalamic nucleus deep brain stimulation on reducing medication in Parkinson´s disease patients. Background: Parkinson's disease (PD) is…Imaging Analysis of the International Tourette Syndrome Deep Brain Stimulation Registry and Database
Objective: We performed a retrospective analysis of Tourette syndrome (TS) patients receiving deep brain stimulation (DBS) therapy as part of the Tourette Association of America…Motor speech and swallowing phenotype of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS)
Objective: To provide a comprehensive quantitative and qualitative characterization of speech and swallowing function in ARSACS to support diagnostics, provide insights into the underlying pathology,…MicroRNAs Unveil Metabolic Imbalance in Spinocerebellar Ataxia Type-2
Objective: To correlate differentially expressed non-coding microRNA of peripheral blood mononuclear cells (PBMCs) with SCA2 pathogenesis. Background: Spinocerebellar ataxia aype-2 (SCA2), the most common SCA…
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