Baseline predictors of clinical and imaging progression in Parkinson’s disease: Results from the PPMI study
Objective: To identify clinical, imaging, and biochemical measures, obtained early in the disease course that predict clinical and dopamine transporter (DAT) imaging progression in PD.…Pronounced synucleinopathy and nigrostriatal degeneration result in forelimb use deficits in the rat preformed alpha-synuclein fibril model
Objective: Generation of a synucleinopathy model in rats using injections of α-synuclein preformed fibrils (α-syn PFFs) resulting in robust and widespread α-syn pathology and at…Speech and Language Therapy (SLT) for Inpatients with Parkinson’s (IwP) in a Large District General Hospital
Objective: To improve access to SLT for the MDT and IwP at the Royal Berkshire Hospital. Background: A successful bid in Jan 2017 for a…Is there a role for miRNA in the diagnosis of PD?
Objective: Several studies have examined mirco RNA (miRNA) in Parkinson's disease with the aim of finding a diagnostic test; so what utility have miRNA in…Spectrum of movement disorders in patients of autoimmune encephalitis of non-neoplastic aetiology
Objective: To study the spectrum of movement disorders and the response to immunotherapy in patients of autoimmune encephalitis of non-neoplastic aetiology. Background: Antibody mediated non…A Case of Parkinsonism due to the Hypoxic-Ischemic Lesions of the Striatum
Objective: To present a case of parkinsonism due to the hypoxic-ischemic lesions of the striatum. Background: Parkinsonism due to the basal ganglia lesions caused by…Cognitive impairment in multiple system atrophy: A Nepalese tertiary center study
Objective: This study was done to describe the clinical profile of MSA and evaluate the cognitive function using mini-mental state examination(MMSE). Background: Multiple system atrophy…Progressive Supranuclear Palsy and Eye of the Tiger Sign
Objective: To report a typical progressive supranuclear palsy case with "eye of the tiger sign" on MRI Background: Progressive supranuclear palsy (PSP); is a degenerative…Evolution of diagnostic certainty and PSP-predominance types in 187 pathologically confirmed PSP patients
Objective: To examine the evolution of diagnostic certainty and clinical predominance types as defined by the movement disorder society (MDS) criteria for the clinical diagnosis…PBT434 prevents the accumulation of glial cell inclusions and insoluble alpha-synuclein in a mouse model of Multiple System Atrophy
Objective: To evaluate PBT434 in a transgenic mouse model of multiple system atrophy (MSA) Background: PBT434 is a novel quinazolinone inhibitor of iron-mediated protein accumulation…
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