Deep Brain Stimulation of Globus Pallidus Internus Combined with Bilateral Anterior Capsulotomy for the Treatment of Tardive Dystonia in Patients with Refractory Schizophrenia
Objective: To evaluate the utility and safety of deep brain stimulation (DBS) of the globus pallidus internus (GPi) combined with bilateral anterior capsulotomy in the…The Adaptation of Card Games for Education in Movement Disorders
Objective: The objective of this project was to develop and use adapted interactive card games for education in movement disorders. Background: There is a clear…Compound-heterozygous mutations in VPS13D are a novel cause of spastic ataxia and lead to mitochondrial dysfunction
Objective: To identify the genetic cause in two sisters with spastic ataxia and to functionally characterize mitochondrial function in patient-derived cells. Background: Spastic ataxia is…Effect of Cold Compression Before Botulinum Neurotoxin Injection in Hemifacial Spasm
Objective: To compare effect of cold compression and no cold compression before Botulinum neurotoxin (BoNT) injection on severity, frequency of hemifacial spasm (HFS) and complication…Carbon Monoxide Poisoning-Induced Parkinsonism: A Prospective Study of Clinical and Neuroimage Correlation
Objective: To investigate prospectively the nigrostriatal system in patients with delayed post-anoxic Parkinsonism by TRODAT-1 brain SPECT serially and to correlate the neuropsychiatric performance and…Patterns of dopamine transporter imaging in subtypes of Multiple System Atrophy
Objective: To investigate the differences in the pattern of striatal (caudate and putamen) dopamine transporter(DAT) loss in a multiple system atrophy (MSA) cohort, based on…Neuroprotective effects of coffee ingredients against rotenone-induced neurodegeneration in parkinsonian model
Objective: In this study, we examined neuroprotective effects of coffee ingredients, caffeic acid (CA) and chlorogenic acid (CGA), against rotenone-induced neurodegeneration using primary cultured cells…Novel biomarkers of autonomic regulation and sleep in Parkinson’s Disease derived from Network Physiology
Objective: Utilize a novel Network Physiology approach to identify new biomarkers of Parkinson’s Disease (PD) based on the dynamics on individual physiological systems, and their…Emulating the natural timing of dopamine receptor activation in Parkinson’s Disease
Objective: To emulate physiological dopamine receptor activation, in order to restore temporal patterns of dopamine-like signalling and normalise function in the striatum in Parkinson's disease.…Impact of SYN120 (a Dual 5-HT6/5-HT2A antagonist) on psychiatric symptoms in patients with Parkinson’s disease dementia: Results from a Phase 2a Study
Objective: To assess the psychiatric effects of SYN120 in patients with Parkinson's disease dementia (PDD). Background: SYN120 is a dual antagonist of serotonin (5-HT6 and…
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