First-In-Human Study of LY3154207, a Dopamine D1 Receptor Positive Allosteric Modulator (D1PAM)
Objective: Evaluate the safety, tolerability, and plasma and cerebrospinal fluid (CSF) pharmacokinetics (PK) of LY3154207 (LY) following oral dosing in healthy subjects (HS). Background: LY,…Long-term safety and efficacy of rimabotulinumtoxinB in the treatment of adult sialorrhea
Objective: To assess the safety, tolerability and effectiveness of repeated rimabotulinumtoxinB injections in adults with troublesome sialorrhea over a period of 1 year. Background: Sialorrhea…A Human Factors Study of the DopaFuse® Delivery System
Objective: SynAgile has developed the DopaFuse Delivery System to noninvasively and continuously administer oral LD/CD into the mouths of patients with PD. The System is…The evaluation of exosomes as a biomarker of Parkinson’s disease
Objective: This study is aimed to investigate whether the number and the contents of serum exosomes can serve as a useful biomarker for the diagnosis…Effects of Virtual Reality Exercise Program using the Sony PlayStation 2 gaming platform on Balance, Emotion and Quality of Life in Patients with Parkinson’s Disease
Objective: This study was to investigate the effectiveness of a 12-week virtual reality(VR) exercise program designed around low-cost VR device, the Sony PlayStation 2 (PS2) gaming…Biphasic Dyskinesias in Parkinson’s disease Patients treated with Levodopa/Carbidopa Intestinal Gel: Insights from a Multicenter Retrospective Analysis
Objective: We aimed to characterize Parkinson's disease (PD) patients who developed the onset of new troublesome dyskinesias after Levodopa-Carbidopa Intestinal Gel (LCIG) initiation. We were…Opicapone improves motor and non-motor wearing off symptoms in Parkinson’s disease: an observational real-world study
Objective: To assess the impact of opicapone - a third generation COMT Inhibitor - on motor and non-motor wearing off symptoms in patients suffering from…Evaluation of neuroprotection by human ENGRAILED-1 in a chronic AAV-hα-synuclein-A53T (AAV-A53T) rat model of Parkinson Disease
Objective: Investigate the long-term neuroprotective effect of a single bilateral injection of human ENGRAILED1 (hEN1) in a rat α-synuclein model of Parkinson Disease (PD). Background:…Transcranial Direct Current Stimolation (tDCS) on PD Patients with Freezing of Gait: Preliminary Findings
Objective: The primary endpoint of this study was to evaluate the effect of a transcranial direct current stimulation (tDCS) protocol with anodal stimulation of the…Yerba mate tea (Ilex paraguariensis) exerts a neuroprotective effect on intrastriatal 6-OHDA-lesioned mice model of Parkinson’s disease
Objective: We set to investigate the possible neuroprotective effect of yerba mate (YM) consumption on dopaminergic neurons in a mice model of Parkinson’s disease (PD). Background: The motor…
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