Swallowing assessment in Parkinson’s Disease using Dynamic Magnetic Resonance Imaging (dMRI)
Objective: To evaluate any dysphagia-signs in Parkinson’s disease (PD) with technique that is non-invasive, without-radiation-exposure and gives good soft-tissue contrast. Background: Swallowing, a basic oromotor…Impaired lysosomal catabolism of alpha-synuclein in parkinsonian LRRK2(R1441G) mutant mouse embryonic fibroblasts
Objective: Using a unique fluorescence-based flow cytometry assay on LRRK2(R1441G) mutant mouse embryonic fibroblasts (MEFs) to elucidate whether pathogenic LRRK2 mutation affects cellular lysosomal degradation…Concomitant brain pathologies have no major impact on clinical milestones in progressive supranuclear palsy
Objective: To analyze the frequency and severity of co-pathologies in PSP patients and their relevance for the clinical presentation and progression in PSP. Background: The phenotypic…Progressive Parkinsonism and Cognitive Changes: A Rare Presentation of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS)
Objective: To describe a rare manifestation of a case of CLIPPERS with video-based documentation of treatment responsiveness. Background: CLIPPERS is a rare inflammatory disease of…Comorbid Parkinson’s disease and Myasthenia Gravis: A Case-Control Study
Objective: To evaluate the clinical features of patients with Parkinson’s Disease (PD) with versus without comorbid Myasthenia Gravis (MG). Background: The recognition of the co-occurrence…Increased vesicular monoamine transporter alleviate MPTP-induced impairment of neurogenesis
Objective: In this study, we employed vesicular monoamine transporter 2–overexpressing mice (VMAT2-HI) to investigate the influence of increased vesicular storage of catacholamines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced…Amimia in Parkinson’s Disease and its Relationship with Motor and Non-Motor Symptoms
Objective: To asses the correlation of amimia (facial bradykinesia) with motor and non-motor symptoms (cognition and depression) in Parkinson´s disease (PD) patients. Background: Reduced facial expression,…Identification of protein biomarker/s in CSF of Parkinson’s disease (PD) with cognitive impairment
Objective: i. To identify CSF protein biomarker/s in Parkinson's disease (PD) with cognitive impairment using LC-MS/MS proteomics. ii. To estimate the level of known AD…Cognitive dysfunction can predict the body weight loss in patients with Parkinson’s disease
Objective: The objective of this study was to examine the predictors of body weight loss in PD patients over years. Background: Early body weight loss…Stimulation Frequency and Active Contact Location Influence Speech Problems in Parkinson’s Disease Patients with Bilateral Subthalamic Deep Brain Stimulation
Objective: This study aimed to identify the prevalence of speech problems including stuttering and hypophonia in patients with Parkinson’s disease (PD). Participants with or without…
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