Speculation on the timing of iron deposition in the putamen of patients with multiple system atrophy: multimodal MRI study
Objective: We sought to investigate the temporal pattern of iron deposition in the putamen of patients with multiple system atrophy (MSA) by calculating conditional probabilities…Increased vesicular monoamine transporter alleviate MPTP-induced impairment of neurogenesis
Objective: In this study, we employed vesicular monoamine transporter 2–overexpressing mice (VMAT2-HI) to investigate the influence of increased vesicular storage of catacholamines on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced…Amimia in Parkinson’s Disease and its Relationship with Motor and Non-Motor Symptoms
Objective: To asses the correlation of amimia (facial bradykinesia) with motor and non-motor symptoms (cognition and depression) in Parkinson´s disease (PD) patients. Background: Reduced facial expression,…Identification of protein biomarker/s in CSF of Parkinson’s disease (PD) with cognitive impairment
Objective: i. To identify CSF protein biomarker/s in Parkinson's disease (PD) with cognitive impairment using LC-MS/MS proteomics. ii. To estimate the level of known AD…Cognitive dysfunction can predict the body weight loss in patients with Parkinson’s disease
Objective: The objective of this study was to examine the predictors of body weight loss in PD patients over years. Background: Early body weight loss…Stimulation Frequency and Active Contact Location Influence Speech Problems in Parkinson’s Disease Patients with Bilateral Subthalamic Deep Brain Stimulation
Objective: This study aimed to identify the prevalence of speech problems including stuttering and hypophonia in patients with Parkinson’s disease (PD). Participants with or without…Apigenin loaded Phospholipid based nanoemulsion in Therapeutics of Parkinson’s Disease Via Attenuation of Oxidative Stress and Upregulation of Dopamine.
Objective: The aim of the present study was to develop, optimizes and evaluate the antiparkinson effects of apigenin loaded phospholipid based nanoemulsion via attenuation of…Early stage Parkinson’s disease patients with GBA mutation have more severe motor symptoms and difficult to differentiate in routine clinical practice
Objective: The objective of this study is to compare clinical features of early stage of Parkinson’s disease (PD) between with and without positive glucocerebrosidase (GBA)…The frequency and impact of mutations in the GBA gene and APOε4 polymorphisms on the clinical features of Dementia with Lewy Bodies among Ashkenazi Jews
Objective: We aimed to explore the frequency and clinical impact of GBA mutations and APOε4 polymorphisms in a cohort of Ashkenazi Jewish (AJ) patients with…The association between frailty and Parkinson’s in the ReSPOnD trial
Objective: To assess the prevalence of frailty in a cohort of people with idiopathic Parkinson's disease, and investigate the factors associated with frailty. Background: Frailty…
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