Alpha-synuclein preformed fibril (PFF)-triggered synucleinopathy recapitulates neurochemical features of human PD: A PET study in rats
Objective: To investigate longitudinal dopaminergic deficits and similarity to human Parkinson’s disease (PD) using PET imaging in the rat alpha-synuclein (a-syn) preformed fibril (PFF) model.…In vivo markers of anxiety in drug-naïve Parkinson’s disease
Objective: To investigate imaging and CSF markers of disease pathology associated with anxiety in drug-naïve idiopathic Parkinson’s disease (PD) patients. Background: Anxiety is a frequent…Walking and Turning of Parkinson’s Disease – Impacts of Freezing of Gait
Objective: This study aimed to find the comprehensive characteristics of locomotion in PD, including forward- and backward walking and turning, especially the impact of FoG.…LFP in motor subtypes of Parkinson’s disease
Objective: To evaluate the power spectrum of LFPs in motor subtypes of Indian PD patients. Background: Though the motor subtypes of the Parkinson’s disease (PD)…The role of dopamine mis-metabolism in preclinical Parkinson’s disease olfactory deficits
Objective: To gain an understanding of the underlying pathological mechanisms of Parkinson’s disease (PD)-related hyposmia using post-mortem human olfactory bulbs and an in vivo model…Serum molecular markers and non-motor symptoms in Parkinson’s disease
Objective: The aim of this study was to examine the association between several serum molecular markers and different measures of non-motor symptom burden in PD.…Poor Sleep Quality is Associated With Fatigue in Early Parkinson’s Disease: A Longitudinal Study in the Early Parkinson’s Disease Longitudinal Singapore Study (PALS) Cohort
Objective: This study aims to explore the associations between baseline sleep quality and the progression of other non-motor symptoms in early Parkinson’s disease (PD). Background:…Trajectories of pain in newly diagnosed Parkinson’s disease
Objective: To determine the frequency and stability of pain over time in a cohort of patients with early Parkinson’s disease (PD). Background: Pain is a…Frequency of Wearing-Off Symptoms in Parkinson’s disease Fluctuators: An on/off evaluation
Objective: To determine if the frequency of wearing-off symptoms in Parkinson’s disease (PD) patients who report fluctuations differs from patients without fluctuations. Background: Wearing-off, the…Difference in olfactory impairment between tremor dominant and akinetic rigid dominant Parkinson’s disease patients
Objective: To investigate difference in olfactory impairment between tremor dominant (TD) and akinetic rigid dominant (ARD) Parkinson’s disease patients. Background: PD can be classified in…
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