Opicapone management: A 2-year follow up real- life practice study
Objective: The aim of this work is to show our clinical experience with opicapone in real practice in a cohort of 68 parkinsonian patients followed…Effectiveness of onabotulinumtoxinA on reduction of rest tremor in Parkinson’s disease: A pilot study
Objective: To determine the feasibility of a prospective study design aimed specifically at comparing the effect of onabotulinumtoxinA (BOT-A) to placebo injections on persons with…Physiologically-based pharmacokinetic modeling of nilotinib to determine serum, cerebrospinal fluid, and brain exposures
Objective: To construct a physiologically-based pharmacokinetic (PBPK) model for predicting nilotinib pharmacokinetics (PK) in plasma and cerebrospinal fluid (CSF); and, to compare model-predicted serum and…Sleep-related Symptoms in Multiple System Atrophy: Determinants and Impact on disease severity
Objective: To investigate the prevalence and determinants of sleep-related symptoms in multiple system atrophy (MSA) and the impact of sleep disturbances on disease severity. Background:…Morphology and Signal Changes of the Lentiform Nucleus Based on Susceptibility Weighted Imaging in Parkinsonism predominant Multiple System Atrophy
Objective: This present case-control study was aimed to investigate both morphological and signal intensity changes in susceptibility weighted imaging(SWI) of the Lentiform Nucleus (LN) for…Progressive supra nuclear palsy phenotype with idiopathic basal ganglia calcification
Objective: To present a rare case of progressive supra-nuclear gaze palsy (PSP) in a patient with idiopathic basal ganglia calcification in a patient with idiopathic…Microbiome from Parkinson’s patients shows an increase in polyamines metabolism and differentially expresses microbial bacterial taxa compared to aged-matched normal controls
Objective: The goal of this study was to determine whether the microbiome from Parkinson’s disease (PD) has alterations in a) Polyamine metabolism and b) Expressed…Changes in the AKT/GSK3 pathway in the cerebellum increase susceptibility to movement disorders in a rat model of post-traumatic stress disorder
Objective: In an effort to investigate the role of PTSD in the aetiology of movement disorders, we assessed changes related to PTSD using the neurotrophic…Psychometric properties of clinical indicators of device-aided therapy eligibility among Parkinson’s disease patients: Real-world data from 6 countries
Objective: Evaluate the performance of clinical indicators for Device-aided Therapy (DAT) eligibility in real-world setting. Background: Timely initiation of appropriate DAT may improve quality of…Speech biometrics can predict cerebellar dysfunction in multiple sclerosis
Objective: To objectively describe cerebellar mediated speech function using a multiparameter index that reflects pathology and quality of life in MS. Background: Cerebellar function plays…
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