Is early-onset of levodopa-induced dyskinesia a predictor of GBA mutation? A next-generation sequencing study of young-onset Parkinson’s disease patients in Thailand
Objective: To examine the prevalence of genetic causes in young-onset Parkinson’s disease (YOPD) patients with levodopa-induced dyskinesia (LID) in Thailand using a next-generation sequencing (NGS)…Characterization of Lewy bodies-induced neurodegeneration and synucleopathy in wild-type mice
Objective: To investigate the Lewy-body-induced degeneration and synucleopathy in wild-type mice while focusing upon origin of the Lewy bodies. Background: Neurodegenerative diseases, such as Parkinson’s…Loss of CHCHD2 and CHCHD10 disrupts mitochondrial cristae phenocopying patient mutations
Objective: Characterization of novel of a novel CHCHD2 (C2) and CHCHD10 (C10) knockout mouse model. Background: Dominant mutations in the mitochondrial paralogs CHCHD2 (C2) and…Predictors of Underlying Neurodegeneration in Drug-Induced Parkinsonism
Objective: To examine a cohort of Veterans with drug-induced parkinsonism (DIP) using [123I]Ioflupane single photon emission computed tomography (DAT-SPECT) to identify those with nigrostriatal degeneration…Inter-network connectivity dynamics underlie compensatory mechanisms in prodromal Parkinson’s disease
Objective: We aimed to investigate the dynamics of inter-network connectivity among non-manifesting GBA and LRRK2 mutation carriers. Background: The prodromal phase of Parkinson’s disease (PD)…Hyposmia as a biomarker in patients with Parkinson’s disease and atypical Parkinsonism
Objective: To investigate neural correlates associated with olfactory dysfunction using fMRI and EEG in Parkinsonism. Background: Patients with Parkinsonism experience non-motor symptoms during the onset…Levodopa-induced dyskinesias and substantia nigra dopamine D3 receptor availability in Parkinson’s disease
Objective: To investigate with PET and the radioligand [11C]PHNO whether levodopa-induced dyskinesias in Parkinson disease (PD) are associated with dopamine-D3 receptor (D3R) overexpression in substantia nigra…Application of substantia nigra feature extraction in the progression of Parkinson’s disease based on magnitude image of susceptibility weighted imaging
Objective: This present study was aimed to investigate the potential value of the substantia nigra (SN) radiomic feature for the prediction of PD progression. Background:…Impairment of the mesocortical dopamine system in Parkinson’s disease patients with freezing of gait in a multimodal imaging approach
Objective: To investigate the involvement of dopaminergic systems in Parkinson’s disease (PD) patients with freezing of gait (FOG) using a multimodal assessment involving 18 F-DOPA-PET…Functional connectivity and volumetric data improve prediction of DBS outcomes
Objective: To determine the clinical utility of neuroimaging markers to predict motor outcomes for deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson…
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