Correlation of Lead Location with Clinical Outcomes in a Double-Blinded Randomized Controlled Trial Evaluating Subthalamic Deep Brain Stimulation in Parkinson’s Disease (INTREPID)
Objective: To assess the relationship between lead location in the subthalamic nucleus (STN) and deep brain stimulation (DBS) outcomes as reported in the INTREPID clinical…A New Web-Based Tapping Test for Measuring Distal Bradykinesia in Parkinson’s Disease
Objective: 1. To develop a web-based test that objectively measures distal bradykinesia, 2. To validate the test by assessing PD patients and healthy controls, and…Real-World Evidence for a Smartwatch-based Parkinson’s Motor Assessment App in Patients Undergoing Therapy Changes
Objective: We sought to investigate patient and clinician usability of a smartwatch-based wearable motor assessment system for measuring Parkinson’s disease (PD) motor symptoms in patients undergoing…Instrumented Detection of Fluctuations with Wearable Devices in Parkinson’s Disease
Objective: The objective of this study is to evaluate the efficacy in fluctuations detection of a system consisting of wearable devices embedding Inertial Measurement Units…Wearable sensors: a real-world characterization of Parkinson’s disease
Objective: To develop and validate new outcome measures of Parkinson's disease (PD) using wearable sensors (MC10, BioStamp nPoint®) in a natural history study of four…Cerebellar structural covariance networks in young people with Tourette syndrome
Objective: To investigate discrete structural brain networks in children and adolescents with Tourette syndrome [TS] relative to a group of matched control participants. Background: TS…Efficacy and safety of CX-8998 in T-CALM, a randomized, double-blind, placebo-controlled, phase 2a trial in participants with essential tremor: subgroup analysis by baseline tremor severity
Objective: Evaluate efficacy and safety of CX-8998 in essential tremor (ET) as a function of baseline tremor severity. Background: CX-8998, a selective modulator of T-type…Essential tremor and essential tremor plus are essentially similar on electrophysiological tremor analysis
Objective: To compare the electrophysiological characteristics of tremor in subjects with Essential Tremor (ET) and Essential Tremor Plus (ET Plus). Background: Patients with neurological signs…Nurse led intrajejunal levodopa pathway for a regional neurosciences centre
Objective: To evaluate the impact of introducing a nurse led advanced therapy service for patients referred for levodopa/carbidopa intestinal gel (LCIG). Background: Leeds Teaching Hospitals…Novel Dentato-Olivo-Luysian Atrophy in a Greek Family
Objective: To describe a unique Greek family with a Dentatorubral-pallidoluysian atrophy (DRPLA) like clinical presentation and a distinctive neuropathological phenotype. Background: DRPLA is a cause…
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