White Matter Changes and Early Cognitive Impairment in Parkinson’s Disease
Objective: Studying white matter changes in Parkinson's disease patients using diffusion tensor imaging; and its relation to cognition and motor symptoms impairment. Background: Cognitive dysfunction…Regional cortical thickness alterations in PD patients with cognitive impairment
Objective: To evaluate the cortical thickness alterations in cognitively impaired patients with PD (PD-CI) in a comparative study with cognitively normal patients with PD (PD-CN)…Clinician Ratings of Cognition Predict Trajectory of Cognitive Decline in Newly Diagnosed Individuals with Parkinson’s disease
Objective: The overall goal of this study was to learn whether clinician ratings of cognition would predict trajectory of changes in memory performance over a…Comparison of gait pattern characteristics during Parkinson’s disease progression – Analysis of gait during the dual-task walking
Objective: We investigated gait characteristics and contribution of clinical presentation and cognitive functioning to the gait characteristics in different Parkinson’s disease (PD) stages. Our aim…Early cognitive impairment is associated with specific regional cholinergic denervation in Parkinson’s disease
Objective: To evaluate regional cholinergic correlates of cognitive impairment in newly diagnosed, treatment-naïve Parkinson’s disease (PD) patients. Background: Mild cognitive impairment (PD-MCI) is a common…The variants of autophagy genes of early-onset Parkinson’s disease
Objective: Early-onset Parkinson’s disease (EOPD) can be linked to different genetic backgrounds than non-EOPD. Therefore, we evaluated 52 patients with EOPD from 4 hospitals in…Enriched burden of rare coding variants in hereditary parkinsonism genes in Parkinson’s disease
Objective: Under a hypothesis that a burden of damaging rare coding variants is increased in causative genes for hereditary parkinsonism, we analyzed burdens of rare…Identification of Parkinson’s disease predisposition genes in high-risk pedigrees
Objective: To identify families with an increased risk of Parkinson’s disease (PD) and the gene variants associated with such increased disease risk studying large multi-generation…LIPAD (LRRK2/Luebeck) International Parkinson’s Disease Study: Detecting genetic and environmental modifiers of penetrance and disease expression
Objective: The international multicenter LIPAD study is a deep-phenotyping, follow-up study to ROPAD (Rostock Parkinson’s Disease Study) with the aim to systematically characterize Parkinson's disease…Emergence of stealth polymorphs that escape α-synuclein amyloid monitoring, take over and acutely spread in neurons
Objective: To unravel the existence of stealth polymorphs of α-synuclein. Background: The conformational strain diversity characterizing α-synuclein (α-syn) amyloid fibrils is possibly at the origin of the…
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