Characterization of novel alpha-synuclein aggregation model of Parkinson’s disease
Objective: To establish and characterize a robust alpha-synuclein (aSyn) aggregation pathology research model to allow efficient drug development platform for Parkinson's disease (PD). Background: PD…The cold hand sign in multiple system atrophy: prevalence, associated factors and impact on survival
Objective: The purpose of the study was to investigate the prevalence of and factors associated with cold hand sign in multiple system atrophy (MSA) patients,…Clinical profile and cerebral metabolic characteristic of cognitive impairments in multiple system atrophy
Objective: This study aimed to characterize the cognitive profiles of multiple system atrophy (MSA) and explore the possible mechanisms involved using 18F-fluorodeoxyglucose (FDG) Positron Emission…Decline in the midbrain-to-pons ratio over one year can support the differentiation between PSP and IPD
Objective: The midbrain-to-pons ratio (MTPR) is considered as an important diagnostic biomarker to differentiate between progressive supranuclear palsy (PSP) and idiopathic Parkinson’s disease (IPD). Here,…Apomorphine as a Diagnostic tool to Identify Levodopa Responsive Atypical Parkinsonism
Objective: To assess the efficacy of apomorphine in identification of levodopa responsive atypical parkinsonism. Background: Management of atypical parkinsonism is a challenge. Most of these…Burden of Care-Partners of People with Parkinson’s Disease: Findings from Parkinson’s Disease Real-World Impact Assessment (PRISM) Study
Objective: To evaluate the characteristics and burden of the care-partners of people with Parkinson’s disease (PwP). Background: The burden of care-partners of PwP is currently…Clinical outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency (PTPSd)
Objective: To assess morbility and clinical outcome of patients affected by defect of tetrahydrobiopterin (BH4) synthesis due to PTPSd. Background: PTPSd is a treatable genetic disorder…Predictors of Falls with Injuries in People with Parkinson’s Disease
Objective: To identify predictors of falls with injuries in people with Parkinson’s disease (PD). Background: Falls are common in people with PD and can lead…Physical Therapy and Deep Brain Stimulation in Parkinson Disease: A Pilot Randomized Controlled Trial
Objective: To determine the safety, feasibility, and preliminary efficacy of physical therapy (PT) for people with Parkinson disease (PD) who have deep brain stimulation (DBS).…Physical Therapy Role with Differential Diagonosis and Treatment with Dizziness and Multiple System Atrophy: A Case Study
Objective: The purpose of this case study is to address the role of physical therapy (PT) in a case of complex dizziness, progressive symptoms, and…
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