Opicapone’s added benefit as a first-line adjunctive therapy to levodopa and when used promptly in the motor fluctuations spectrum of Parkinson’s disease: a post-hoc analysis of BIPARK-I and II
Objective: To evaluate opicapone (OPC) in Parkinson’s disease (PD) patients with motor fluctuations according to disease- and therapy-related characteristics. Background: OPC, a once-daily catechol-O-methyltransferase inhibitor,…Comparing the effects of rosemary and selegiline on behavioral symptoms of Parkinson’s animal model in mice
Objective: Parkinson is from common disorders of central nervous system and the second disease in neurodegenerative diseases which occurs in 1% of people over the…High Satisfaction and Improved Quality of Life with Rock Steady Boxing in Parkinson’s Disease
Objective: To compare demographics, self-reported symptom burden, Health-Related Quality of Life (HRQL), and Exercise Self-Efficacy (ESE) between Rock Steady Boxing (RSB) participants and non-participants. Background:…Pharmacokinetics of Levodopa in patients with Parkinson’s disease: Efforts toward a predictive model
Objective: Our aim was to explore correlations between the pharmacokinetics of levodopa (LD) and clinical manifestation in patients with Parkinson’s disease (PD). Our goal was…Indication and long-term outcome of device-aided therapies in advanced Parkinson’s disease
Objective: We aimed to demonstrate the real world differences in a single center. Background: Number of deep brain stimulation (DBS) and levodopa-carbidopa continuous infusion gel…Identification and characterization of anti-prionic compounds that disassemble αSyn prions as a novel therapeutic approach for synucleinopathies
Objective: Stabilization of monomeric α-synuclein protein (αSyn) by transient and high-affinity binding ligands is a novel and highly innovative anti-prionic treatment strategy for synucleinopathies .…Relationship between REM sleep without atonia and sleep architecture in multiple system atrophy
Objective: To investigate whether REM sleep without atonia (RWA) is associated with sleep architecture in patients with multiple system atrophy (MSA). Background: In MSA patients,…Correlations between amantadine usage, gait, and cognition in PSP: a post hoc analysis of the davunetide trial
Objective: Amantadine anecdotally improves gait and balance in PSP, potentially by increasing alertness, but there are no definitive data to support this observation. We investigated…Temporhythmal Correction: The New Way of Therapy and Diagnostic Secondary Vascular Parkinsonism
Objective: It is known that, in vascular parkinsonism (VP) and Parkinson’s disease (PD) it is observed shortening of steps, bradikinesia, oligokinesia, gait disorders and also…May Safinamide have a Role in Atypical Parkinsonism? A Retrospective Study in Clinical Practice
Objective: To evaluate efficacy and safety of safinamide in atypical parkinsonian syndromes. Background: Safinamide (50-100 mg) has proved efficacy as an add-on treatment to levodopa…
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