Insomnia may have a mediating role in linking Parkinson’s disease severity to depression and anxiety
Objective: The aim of this study was to investigate the role of insomnia in relationship of disease severity with depression/anxiety in patients with Parkinson’s disease…Selective α-synuclein overexpression-induced pathology in noradrenergic neurons: a new mouse model for prodromal Parkinson’s disease?
Objective: To investigate the phenotype of noradrenergic (NA) neurons in an animal model with selective overexpression of α-synuclein (αSyn) in the locus coeruleus (LC) with…Spreading ɑ-synuclein pathology initiated from the sublaterodorsal tegmental nucleus models RBD followed by Parkinsonian phenotypes in mice
Objective: To recapitulate ɑ-synucleinopathy based RBD-like behaviors in mice which could further proceed to develop Parkinsonian behavioral and histopathological phenotypes. Background: Idiopathic REM sleep behavior…Profiling Atypical Anxiety in Parkinson’s Disease
Objective: We aimed to identify the demographic, psychiatric, clinical and cognitive characteristics associated with Anxiety not otherwise specified (NOS) in persons with Parkinson’s disease (PWP).…Impulse control disorder in the patients of Parkinson’s disease: Various correlations
Objective: 1. To estimate the point prevalence of ICD in the local cases of PD using the series of rating scales. 2. To examine the…A retrospective analysis of multicenter brain signal data recorded in Parkinson’s subjects implanted with deep brain stimulation leads
Objective: To assess the prevalence and factors of detectable local field potential (LFP) signals in the subthalamic nucleus (STN) of Parkinson’s disease (PD) patients. Background:…Varenicline for the Treatment of Postural and Gait Dysfunction in Parkinson’s Disease
Objective: To determine if varenicline is effective for balance in Parkinson’s disease (PD). Background: Incidence of falls resulting from imbalance is estimated at 68% for…Apomorphine Sublingual Film for On-Demand Treatment of “OFF” Episodes in Patients With Parkinson’s Disease: Impact on Dyskinesia
Objective: Assess impact of apomorphine sublingual film (APL-130277; APL) on time spent with and functional impact of dyskinesia among patients with Parkinson’s disease (PD) and…Serious games home rehabilitation program to treat gait and balance disorders in patients with Parkinson’s disease: A randomised controlled trial
Objective: To test the efficacy of an exergame rehabilitation programme at home to treat dopa-resistant gait and balance disorders in Parkinson’s disease (PD) patients. Background:…Directional versus Omnidirectional Deep Brain Stimulation: Results of a Multicenter Prospective Blinded Crossover Study
Objective: To compare the range of stimulation amplitudes that can relieve symptoms without side effects, between directional and omnidirectional DBS. Background: Published reports on directional…
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