Rotenone exposure is associated with mitochondrial DNA (mtDNA) damage in humans
Objective: To determine if mtDNA damage can serve as a biomarker of prior pesticide exposure. Background: Mitochondrial dysfunction is a hallmark of PD, and exposure…Compartment-specific blockade of dopamine uptake in nigrostriatal pathway reveals role for nigral dopamine function in movement frequency in open-field
Objective: Inhibition of tyrosine hydroxylase activity in the substantia nigra (SN) produces a significant reduction in locomotor motor activity commensurate with decreased dopamine (DA) content…Identifying de novo Parkinson’s disease with optical coherence tomography of the retina: A machine learning classification approach
Objective: To identify and classify de novo Parkinson’s disease patients compared to healthy controls (HC). Background: PD patients experience visual symptoms and retinal degeneration. Studies…Nucleus basalis of Meynert free-water distinguishes and predicts cognitive impairment and longitudinally correlates with cognitive changes in early Parkinson’s disease
Objective: To explore diffusion-based MRI assessments of the nucleus basalis of Meynert (nbM) as a neuroimaging biomarker of cognitive abilities and longitudinal cognitive changes in…Quantitative Susceptibility Mapping may help distinguish patients with Parkinson’s disease, progressive supranuclear palsy and multiple system atrophy with predominant parkinsonism
Objective: The purpose of this study was to examine quantitative susceptibility mapping (QSM) changes in PD and multiple system atrophy with predominant parkinsonism (MSA-P) and…Dopaminergic denervation in de-novo Parkinson’s disease. Does functional somatotopy plays a role?
Objective: To clarify how dopaminergic denervation occurs along the dorsoventral axis of the posterior putamen in the earliest stages of PD. Background: Dopamine loss in…FDG PET and MIBG scintigraphy in the differential diagnosis of parkinsonism: a head-to-head comparison
Objective: To compare the performance of [18F]fluorodeoxyglucose (FDG) PET and [123I]metaiodobenzylguanidine (MIBG) scintigraphy in the differential diagnosis of parkinsonism in the same patient sample. Background:…Brain atrophy progression in de novo Parkinson’s disease
Objective: Using deformation-based morphometry (DBM) as a measure of atrophy, the aim of this study was to identify the regions presenting structural brain changes after…Differentiating Parkinson’s disease dementia and mild cognitive impairment from idiopathic Parkinson’s disease using machine learning approach
Objective: This paper aims at creating a computer-based diagnosis tool which can predict the classification of MCI and dementia in patients of Parkinson's disease (PD)…Motor asymmetry in Parkinson’s disease: relation with freezing of gait
Objective: To evaluate the relation between motor symptoms asymmetry in patients with Parkinson’s disease (PD) and freezing of gait (FOG) episodes. Background: It is yet…
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