Northwestern University Feinberg School of Medicine Parkinson’s disease and Movement Disorders Center Biorepository: bringing the clinic and lab together
Objective: To establish a biobank of DNA and tissue samples from a population of movement disorder patients, their family members and healthy controls recruited from…Association between SNCA and clinical phenotypes of Parkinson’s disease in southern Chinese
Objective: The aim was to investigate the association between SNCA and clinical phenotypes of Parkinson’s disease (PD) in southern Chinese. Background: SNCA gene plays an…Sensitive biomarker of Parkinson’s disease linked to mutations in the glucocerebrosidase gene
Objective: To find a biomarker for development of Parkinson’s disease (PD) in carriers of mutations in the glucocerebrosidase gene (GBA). Background: Mutations in the GBA…Utility of multigene panel testing for diagnosing parkinsonism and dystonia in a large cohort of >500 patients
Objective: Evaluate the utility of multigene Next-Generation Sequencing (NGS) for molecular diagnosis of parkinsonism and dystonia. Background: Parkinson's disease (PD) and dystonia are common neurodegenerative…Screening of mutations in PARK2 gene and Dopamine levels in Parkinson’s disease (PD) patients in Coimbatore population, India
Objective: The aim of the present study was to perform the mutational screening of PARK2 gene and dopamine level in PD patients of Coimbatore population,…α-Synuclein propagation via olfactory pathway induces olfactory bulb atrophy and widespread glucose hypometabolism in a non-human primate model
Objective: We investigated how α-synuclein (α-Syn) pathology spreads from the olfactory bulb (OB) and how the pathology affects brain structure and activity. Background: Parkinson's disease…Identifying the functional brain network of motor reserve in early Parkinson’s disease
Objective: To explore the functional brain network associated with motor reserve in early-stage Parkinson’s disease (PD). Background: The severity of motor symptoms in PD does…Quantification of 123I-ioflupane Striatal Uptake and Individual Patient Diagnostic Predictions: Degenerative Parkinson’s disease, Non-Degenerative Parkinsonism and Tremor Disorders
Objective: To develop a fully automated quantitative method to analyse routinely acquired 123I-ioflupane (DaTSCAN) data to aid diagnostic predictions in patients with Parkinson’s disease, non-degenerative…Quantitative Susceptibility Mapping for Differential Diagnosis of Degenerative Parkinsonisms: A Comparison with Morphometric Indexes
Objective: To use a multimodal MRI approach for differential diagnosis of patients with degenerative parkinsonisms, comparing the diagnostic accuracy of Quantitative Susceptibility Mapping (QSM) data…Intrinsic Remodeling of the Fovea is Correlated with Contrast Sensitivity Loss in Parkinson’s Disease
Objective: The aim of the study was to determine a technical parameter of foveal pathology that is best suited for discriminating Parkinson’s disease (PD) eyes…
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