Effect of the GlyT1 inhibitor ALX-5407 on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset
Objective: To determine the effect of glycine transporter 1 (GlyT1) inhibition with ALX-5407 on dyskinesia, psychosis-like behaviours (PLBs) and parkinsonism severity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned…Neuroprotective Epigenetic and DNA-Repair Molecular Mechanisms of Acetyl-L-Carnitine and Astaxanthin Against 6-OHDA Induced Parkinsonism in Aged Rats
Objective: Present study was designed to delineate the neuroprotective epigenetic and DNA-damage-repair molecular mechanisms of acetyl-L-carnitine (ALC) and astaxanthin (ASX) against 6-OHDA-induced neurotoxicity in aged…Associations between Exercise Classes and Self-Reported Exercise by People with Parkinson’s Disease at Parkinson’s Foundation Centers of Excellence
Objective: We sought to examine the relationship between the characteristics of Parkinson’s Foundation Center of Excellence (COE)-based and community-based exercise classes and the self-reported hours…Causes of deaths in patients with Parkinson’s disease in the era before the use of modern drug therapy and at the present time
Objective: to study the impact of modern pharmacotherapy of Parkinson's disease (PD) on the main causes of death. Background: the modern era of the use…The responsiveness of arm swing to dopaminergic medication in Parkinson’s disease depends on task complexity
Objective: The aim of this study is to analyse the responsiveness of arm swing during walking to dopaminergic medication in patients with Parkinson’s disease. Background:…Mapping regional alpha-synuclein seeding capacity in Multiple System Atrophy
Objective: The objective of our work was to develop a novel high-throughput cell-free assay that allowed us to perform a comprehensive characterization of α-synuclein seeding…Early detection of change in motor and cognitive symptoms in a longitudinal Progressive Supranuclear Palsy cohort – the OxQUIP study.
Objective: We aimed to determine longitudinal changes in motor and cognitive features of Progressive Supranuclear Palsy using multiple closely spaced follow-up timepoints over a period…Hemiparkinsonism Due to Diencephalic Lesion with 24 Years of Levodopa Response and Only Mild Dyskinesia
Objective: To present a case of a long-standing hemiparkinsonism due to cerebral lesion with a continuous response to a stable dose of levodopa with only…How Covid-19 would affect parkinsonism patients’ mortality
Objective: To investigate the prevalence and mortality of Covid-19 among parkinsonism patients in addition to worsening of motor symptoms of these patients. Background: Parkinsonism can…Association between Alzheimer’s disease co-pathology and neuropsychiatric symptoms in Lewy body dementia
Objective: To identify the associations between Alzheimer Disease (AD) co-pathology and neuropsychiatric symptoms in Lewy body dementia (LBD). Background: Dementia with Lewy Bodies (DLB) and…
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