Developing 31-phosphorus magnetic resonance spectroscopy (31P-MRS) as an imaging biomarker to identify mitochondrial dysfunction in Parkinson’s disease
Objective: To determine if 31P-MRS can identify mitochondrial dysfunction in-vivo and if this correlates with in-vitro measures of mitochondrial function obtained from patient derived fibroblasts…Dysfunctional resting connectivity in early stage of Parkinson’s disease is indistinguishable from connectivity in REM sleep behaviour disorder
Objective: To investigate the differences in functional connectivity among healthy subjects (HC), patients with REM sleep behaviour disorder (RBD) and levodopa-naïve patients in early stage…Distinct cholinergic reactivity to dopamine is related with differed parkinsonian tremor responsiveness
Objective: We aimed at exploring the mechanisms of differed tremor responsiveness to dopamine through investigating the cholinergic and dopaminergic reactivity during dopamine administration in PD.…Impact of the postural function сhanges on quality of life and daily activity in patients with Parkinson’s disease during DBS
Objective: Quality of life (QOL) and activity of daily living (ADL) in PD patients depends on the severity of motor disorders, including changes of postural…Surface EMG signal features of Parkinson’s disease may support interpretation of home-based measurement data
Objective: To define reference values for surface electromyography (EMG) -based signal parameters in Parkinson's disease (PD) based on previously measured data. These reference values may…Effects of Levodopa-Carbidopa Intestinal Gel on Dyskinesia and Non-Motor Symptoms including Sleep: Results from a Meta-Analysis with 24-month follow-up
Objective: To evaluate the impact of levodopa-carbidopa intestinal gel (LCIG) on dyskinesia, sleep, and other non-motor symptoms over 24 months after initiation. Background: Complications of…Fecal Calprotectin in Parkinson’s Disease and Multiple System Atrophy
Objective: To investigate the levels of fecal calprotectin (a marker of intestinal inflammation), in patients with Parkinson's Disease (PD) and multiple system atrophy (MSA) compared…Obstructive sleep apnea and other vascular risk factors’ impact on Non-motor Symptoms in Parkinson’s Disease
Objective: To investigate the relationship between vascular comorbidity and non-motor symptoms in Parkinson’s Disease (PD) patients. Background: Previous studies suggested a significant association between the…Increased non-motor impairment in Parkinson’s disease with REM-Sleep behaviour disorder; cross-sectional analysis in Luxembourg Parkinson’s Study
Objective: To identify specific differences in motor and non-motor profile in Parkinson’s disease (PD) with or without probable REM-Sleep behaviour disorder (pRBD) based on the…IS FATIGUE ASSOCIATED WITH BALANCE IN PARKINSON’S DISEASE?
Objective: The aims of this study were to verify the correlation between fatigue and balance in individuals with PD; to compare balance in individuals with…
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