Elucidating multimodal endophenotypes of APOE-ε4 in α-synucleinopathies
Objective: To systematically identify phenotypes that consistently associate with the ε4-allele of apolipoprotein E (APOE-ε4) in α-synucleinopathies. Background: The APOE-ε4 presents an elevated risk not…Baseline cognitive profile is closely associated with long-term motor prognosis in newly diagnosed Parkinson’s disease
Objective: To investigate the association between cognitive function at baseline and the progression of motor disability in Parkinson’s disease (PD). Background: There is increasing clinical…The volume of STN tissue activated by DBS and the strength of its structural connectivity with SMA predicts the effects of STN-DBS on response inhibition
Objective: To test the hypothesis that antidromic activation of the hyperdirect pathway might mediate the effects of STN-DBS on movement initiation control. Background: In PD,…Alterations in brain functional network connectivity in Parkinson’s disease patients with MCI
Objective: To investigate functional network abnormalities in Parkinson’s disease patients with mild cognitive impairment (PD-MCI) and PD patients who are cognitively normal (PD-NC). Background: Cognitive…The Commercial Genetic Testing Landscape for Parkinson’s Disease
Objective: To evaluate commercial genetic testing offered for Parkinson’s disease (PD) Background: The etiology of PD is complex and, typically, multifactorial. At least 6 genes…GBA variants in a multi-ethnic Parkinson’s disease (PD) cohort in Malaysia
Objective: To investigate the frequency of Glucocerebrosidase (GBA) gene variants in a multi-ethnic Parkinson’s disease (PD) cohort in Malaysia. Background: GBA variants have been associated…Lack of diversity in Parkinson’s disease genetic research: current landscape and future directions
Objective: We conducted a systematic review to summarize past studies on Parkinson's disease (PD) genetics research among underrepresented populations (URP), defined as being non-European ancestry. We…Silencing of hypoxia-inducible factor 1 alpha provokes a neuroprotective response in a SH-SY5Y model of Parkinson’s Disease.
Objective: Our study aims to delineate the role of HIF1α in a SH-SY5Y model of Parkinson’s disease (PD) Background: Parkinson’s disease (PD) is one of…Next-generation sequencing of plasma-associated extracellular vesicle miRNAs as potential biomarkers for Parkinson’s disease and its prodromal stage
Objective: This study aimed to identify subsets of plasma EV-associated miRNAs with diagnostic potential for PD and iRBD, the prodromal stage of PD. Background: Parkinson’s…Metabolic alterations in a Drosophila model of Parkinson’s disease
Objective: Identification of metabolic alterations that could be contributing to Parkinson’s disease (PD) physiopathology and become new biomarkers or therapeutic targets for the disease. Background:…
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