Spinal myoclonus in secondary progressive multiple sclerosis
Objective: We report a rare case of secondary progressive multiple sclerosis with one of the manifestation was spinal myoclonus. Background: Myoclonus is a sudden and…The effects of acute administration of VMAT2 inhibitors on extracellular levels of dopamine, norepinephrine, 5-HT and histamine in the striatum and medial prefrontal cortex
Objective: To evaluate the effects of reversible VMAT2 inhibitors (deutetrabenazine, tetrabenazine and valbenazine) on extracellular levels of monoamines and their acidic metabolites in rat striatum…Closing the Loop on Essential Tremor Using Thalamic and Cortical Control Signals
Objective: In this study, we show feasibility of a novel embedded closed-loop DBS (CL-DBS) that uses local field potential (LFP) oscillations of the alpha/beta band…Evaluation of Care delivery model for integrated care and self-management for people with Parkinson’s disease with Deep Brain Stimulation
Objective: To evaluate the implementation and impact potential of a pragmatic network for PD care, the Integrated Parkinson Care Network (IPCN) for patients with chronic…Alpha-synuclein oligomers detection by proximity ligation assay in skin biopsy is a biomarker for Parkinson’s disease
Objective: To assess the presence of oligomeric alpha-synuclein (αSyn), an early pathogenic species, in skin nerve fibers of patients with Parkinson’s disease (PD) and atypical…The alien hand syndrome
Objective: This case is presented to create awareness of this interesting clinical scenario, which can be terrifying to the patients and confusing to the physicians…Feasibility of Instituting Graduated High intensity Training (FIGHT-PD); Protocol for a non-contact boxing exercise study
Objective: 1. To determine the feasibility and logistics of conducting a non-contact boxing exercise program for PD patients. 2. To determine the tolerability of the…Long-Term Safety and Efficacy of Apomorphine Sublingual Film for “OFF” Episodes in Parkinson’s Disease
Objective: Evaluate long-term safety (LTS), tolerability, and efficacy of apomorphine sublingual film (APL) for on-demand treatment of “OFF” episodes in patients with Parkinson’s disease (PD).…Disease stage and nigrostriatal integrity predict motor progression in individuals with early Parkinson’s disease
Objective: To identify predictors of motor progression in individuals with early Parkinson’s disease (PD), who are either untreated or treated with monoamine oxidase B (MAO-B)…Efficacy of a 6-week brisk walking program in improving non-motor symptoms in people with Parkinson disease – a randomized controlled trial
Objective: To examine whether the brisk walking program would be effective in alleviating non-motor symptoms, and improving sleep quality and health-related quality-of-life (HRQoL) in people…