The potential of GBA1 knock-out medaka as a model animal in the search for therapeutic compounds for GBA1-related α-synucleinopathy
Objective: This study was performed to search for therapeutic agents for GBA1-related α-synucleinopathy. Background: The GBA1 gene is the causative gene of Gaucher’s disease (GD).…Evaluation of a double-target therapeutic in preclinical models of Parkinson’s disease
Objective: To evaluate the effectiveness of a candidate compound identified in a high-throughput screening (HTS) assay carried out in a Drosophila model of Parkinson’s disease…Levodopa responsive gait dynamics in ON- and OFF-state freezing of gait in Parkinson’s disease
Objective: To determine which spatiotemporal gait parameters respond to levodopa in Parkinson’s patients with levodopa ON- and OFF-state gait freezing. Background: Levodopa-ON-state gait freezing is…The Implications of Pyramidal Signs in Multiple System Atrophy
Objective: To determine pyramidal signs in multiple system atrophy (MSA) and the associations with other clinical characteristics. Background: The clinical manifestations of MSA are comprised…Language impairment in Corticobasal Syndrome: from clinical phenotype to biomarkers
Objective: To investigate the language impairment profile of patients diagnosed as probable Corticobasal Syndrome (CBS) [1] in light of a multimodal imaging biomarkers analysis, namely…Dream enactment behavior disorder associated with pallido-nigro-luysian degeneration and tau proteinopathy
Objective: To describe the detailed clinical features and pathological findings of a patient with Pallido-nigro-luysian atrophy (PNLA). Background: PNLA is a rare neurodegenerative disorder with…Time to diagnosis of clinically established Parkinson’s disease or atypical parkinsonism: is a 5-year follow-up period necessary?
Objective: To determine the time frame to the diagnosis of clinically established Parkinson’s disease (PD) or atypical parkinsonism after an acute levodopa challenge (LDC) for…The PRIME Qual study protocol: A qualitative exploration of the experiences of patients, caregivers/families and hospital/intervention staff of the PRIME Randomised Controlled Trial
Objective: This qualitative study seeks to understand how a new model of care influences a person with Parkinson’s ability to stay well physically, maintain their…Event-related oscillations in patients with Dementia with Lewy Bodies with and without mutations in the GBA gene
Objective: To explore the differences in the structure of event-related oscillations (ERO) elicited by a visual oddball task in Dementia with Lewy bodies (DLB) patients…Plasma phosphorylated α-synuclein relates to cognitive impairment in patients with Parkinson’s disease
Objective: To investigate whether plasma phosphorylated α-synuclein (p-syn) were associated with cognitive function in Parkinson’s disease (PD). Background: Parkinson’s disease (PD) is the second most…
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