ABBV-0805, a novel α-synuclein oligomer selective antibody, prolonged lifespan and prevented accumulation of α-synuclein pathology in mouse models of Parkinson’s disease
Objective: We report on the pharmacological characteristics of ABBV-0805 (BAN0805), a monoclonal antibody that exhibits a high selectivity for human α-synuclein oligomers and very low…Influence of onset of motor fluctuations on the effectiveness of opicapone in Parkinson’s disease patients with motor fluctuations: findings from the real-world OPTIPARK study
Objective: This post-hoc analysis evaluated the influence of onset of motor fluctuation (OMF) on the response to opicapone (OPC) treatment in patients with Parkinson’s disease…Influence of Dopamine Transporter Gene Polymorphism on Wearing Off
Objective: To study the influence of Dopamine transporter gene polymorphism on Wearing off (WO) through 19 items wearing off questionnaire (WOQ-19) Background: The dopamine transporter…Combined Plantar Stimulations Using a Novel Parkinson Shoe benefit Parkinson’s Disease Patients with Unresponsive Freezing of Gait
Objective: To explore the effect of combined vibratory and pressure stimulations in PD patients with unresponsive FOG and develop the innovative PD shoe. Background: Freezing…Compensation strategies for gait impairment in Parkinson’s disease: a survey among 4,324 patients
Objective: The aim of this study was threefold: (1) to evaluate patients’ awareness and use of various compensation categories for gait impairments in PD; (2)…Deep gray matter atrophy in MSA subtypes
Objective: To compare MRI parameters of atrophy in Multiple system atrophy (MSA) subtypes. Background: MSA is a rare adult-onset synucleinopathology that can be divided in…Novel Cognitive Markers for Early Diagnosis and Monitoring of Progressive Supranuclear Palsy
Objective: The aim of this study was to evaluate whether a novel computerised test could offer an inexpensive and reliable tool that can aid diagnosis…Mild parkinsonian signs in older adults correlate with an impaired functional level – a cross-sectional general population study from the “Good Aging in Skåne” cohort
Objective: We aimed to investigate the prevalence of MPS and the association with Activities of Daily Living (ADL), cognitive, physical, and autonomic function in adults…EPIDEMIOLOGICAL OVERVIEW OF PARKINSON’S DISEASE IN BRAZIL
Objective: To describe the epidemiological profile in patients hospitalized with Parkinson's Disease in Brazil during the years 2015 to 2020. Background: Parkinson's disease (PD) is…A case of dystonia-parkinsonism associated with a heterozygous PRKRA (DYT16) gene mutation
Objective: We describe the clinical presentation, diagnosis, and treatment of a case of dystonia-parkinsonism associated with a heterozygous mutation in the initiator methionine of the…
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