Lesion-induced chorea-ballismus in Southwest Finland
Objective: To collect and characterize cases of lesion-induced chorea-ballismus and investigate if lesions involve the subthalamic nucleus. Background: Lesion-induced (hemi)chorea-ballismus is a relatively rare disorder,…GT-02287, a brain-penetrant structurally targeted allosteric regulator for glucocerebrosidase show evidence of pharmacological efficacy in conduritol β-epoxide (CBE) models of Parkinson’s disease
Objective: Demonstrate the involvement of our structurally targeted allosteric regulator Parkinson’s disease (PD) candidate, GT-02287, in decreasing the CBE-induced neurotoxic effect and in restoring lysosomal…Spinocerebellar Ataxia Type 5: an Unusual Infantile Onset with Development Delay
Objective: Spinocerebellar Ataxia Type 5 (SCA5) is an uncommon cause of cerebellar ataxia with onset generally within the third and the fourth decade and a…Neuroprotective effects of estradiol and progesterone in brain of different age groups of naturally menopausal rats.: A therapeutic potential drug for Parkinson’s disease
Objective: The objective of this study was to determine the effect of E2 and P4 on the activity of acetylcholinesterase (AChE) and monoamine oxidase (MAO), oxidative stress…Longitudinal Program to Prevent PD (LoPP-PD): Multimodal Risk Stratification Informs Personalized Intervention
Objective: Longitudinal evaluation of personalized intervention strategies informed by detailed clinical and laboratory biomarker analysis to reduce relative risk of Parkinson’s disease in first degree…Apomorphine Sublingual Film Titrated at Home in Patients With Parkinson’s Disease and OFF Episodes: Results From an Open-Label, Randomized, Crossover Study
Objective: Evaluate the ability of patients with Parkinson’s disease (PD) and OFF episodes to achieve an effective and tolerable FULL ON dose of apomorphine sublingual…Chikungunya: An emerging arthropod borne disease presenting as rhombencephalitis with near complete recovery
Objective: To report the clinical course and good neurological outcome of severe Chikungunya rhombencephalitis. Background: Chikungunya is an emerging Aedes mosquito borne virus that is…Gerstmann-Straussler-Scheinker Syndrome Manifesting Levodopa-Responsive Parkinsonism, Levodopa-Induced Dyskinesia, and Abnormal DaT-SPECT
Objective: The objective of this report is to describe previously unreported features in a patient with Gerstmann-Straussler-Scheinker syndrome (GSS) due to the F198S mutation. Background:…Dorsolateral nigral hyperintensity on 1.5 versus 3T susceptibility-weighted magnetic resonance imaging in neurodegenerative parkinsonism
Objective: In contrast to their 1.5T counterparts, high field MRI scanners are often unavailable in clinical routine, particularly in primary care facilities and underserved regions.…Impact on non-motor symptoms, cognition, and QoL after 1-year of DBS for Parkinson’s Disease: An interim report from the ADROIT NAPA sub-study
Objective: To present the impact on cognition, quality of life, and non-motor symptoms after 1-year of DBS for Parkinson’s Disease through the ADROIT post-market study.…
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