CCDC88C p.R464H likely cause a novel late-onset parkinsonism phenotype
Objective: We describe two sisters with late-onset parkinsonism associated with a CCDC88C variant (p.R464H). Background: Tsoi et al. (2014) identified a heterozygous missense mutation in the CCDC88C gene (R464H), by…Learning to PERSEVERE: Efficacy and Feasibility of Peer Mentor Support and Caregiver Education in Lewy Body Dementia
Objective: To examine the effects of peer mentoring on caregiving mastery, Lewy Body Dementia (LBD) knowledge, and dementia attitudes among LBD family caregivers. Background: Few…A dose-response study of the effect of the mGlu2/3 orthosteric antagonist LY-341,495 on the anti-dyskinetic and anti-psychotic effect of the mGlu2 positive allosteric modulator LY-487,379 in the MPTP-lesioned marmoset
Objective: To assess the effects of different doses of the metabotropic glutamate 2 and 3 (mGlu2/3) orthosteric antagonist (OA) LY-341,495 on the anti-dyskinetic and anti-psychotic…The Effect of Oropharyngeal Resting Tremor on Swallow Timings in a Clinical Cohort of People with Parkinson’s Disease
Objective: The objective of the project was to investigate how the presence of resting tremors in oropharyngeal structures impacted swallow timings and duration measures to…A randomized controlled trial comparing the efficacy and safety of pyridostigmine versus midodrine for the treatment of orthostatic hypotension in Parkinson’s disease patients
Objective: To assess the long-term efficacy and safety of pyridostigmine and midodrine in the treatment of OH in PD. Background: In Parkinson's disease (PD), orthostatic…Movement disorders with phosphodiesterase 10A IgG autoimmunity
Objective: To report four new cases of phosphodiesterase 10A (PDE10A) IgG neurological autoimmunity. Background: PDE10A IgG was recently identified as a biomarker of paraneoplastic neurological…Cognitive performance and learning parameters predict response to working memory training in Parkinson’s disease
Objective: The present study aims to evaluate a multivariable model to predict verbal working memory (WM) performance following a targeted cognitive training intervention, WM training…X-Linked Dystonia Parkinsonism as the cause of Isolated Lingual Dystonia (ILD)
Objective: This report aims to describe a 43-year-old Filipino male with ILD aggravated by speech and swallowing. This paper highlights the importance of including XDP…Short report in a dystonia cohort patients with implanted DBS systems
Objective: To review the use of bipolar and monopolar stimulation in a cohort of patients implanted DBS with Generalized Dystonia between 2012-2021 in Federal Center…An automated data cleaning approach to remove preparation artefacts from brain histology slide images
Objective: To present the potential application of an automated image analysis pipeline called WSIQC for the cleaning and quality assessment of brain histology images. Background:…
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