Multimodal assessment of nigrostriatal degeneration in de novo Parkinson’s disease
Objective: To study nigrostriatal changes with a multifactorial neuroimaging approach in order to further characterize early abnormalities in Parkinson’s Disease (PD). Background: Imaging techniques allow…The anti-alpha-synuclein antibody Lu AF82422 was safe and well tolerated in a FIH-SAD study in healthy subjects and patients with PD
Objective: Evaluation of safety, tolerability, pharmacokinetics (PK) and target engagement (TE) in healthy subjects (HS) and patients with Parkinson’s disease (PD) following single ascending doses…The role of intraoperative electrophysiological monitoring in implanting globus pallidus internus electrodes in patients with dystonia
Objective: The first aim was to compare the preplanned GPi electrode neuroradiological trajectory with the final trajectory selected after electrophysiological monitoring. The second aim was…Pooled safety analysis of incobotulinumtoxinA in the treatment of neurological disorders in adults
Objective: To examine the pooled incidence of treatment-emergent adverse events (TEAEs) and immunogenicity by indication in sponsored incobotulinumtoxinA (INCO) clinical trials in adults. Background: The…Emotion Recognition in Multiple System Atrophy – an Eye-Tracking Study
Objective: To get better insights into emotion processing in patients with MSA-P compared to healthy controls (HCs) by using two different Eye-Tracking paradigms. Background: MSA…Choice of shoulder muscles for the multi-pattern treatment of upper limb spasticity with botulinum neurotoxin injections
Objective: To present an experts’ consensus on the use of botulinum neurotoxin (BoNT) injections in the multi-pattern treatment of shoulder spasticity to increase awareness of…A double-blind randomized clinical trial to evaluate the effects of Candesartan for Cognitive and Neuropsychiatric Impairment in Parkinson’s Disease
Objective: To explore the feasibility of repurposing candesartan for the treatment of cognitive impairment and neuropsychiatric symptoms in PD. Background: There is an urgent need…Sigma Absolute Spectral Power is Associated with Depression in Parkinson’s Disease
Objective: This cross-sectional study investigated the relationship between depression and sigma absolute spectral power (9-15 Hz) in the frequency range of sleep spindles during non-rapid…Association Between Over-the-Counter Dietary Supplements and Parkinson’s Disease Symptom Severity Over Time
Objective: The goal of this study was to evaluate whether the use of nutraceuticals and dietary supplements are associated, on a population level, with Parkinson’s…Gene and variant curation of Parkinson’s disease genes by an authoritative expert panel
Objective: Establish an authoritative central curation for causative genes and variants for Parkinson’s disease (PD) Background: The urgency to establish central curation for causative genes…
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