Challenges in Outcome Measure Selection in Multi-Arm Multi-Stage Clinical Trials in Parkinson Disease
Objective: The Edmond J Safra Accelerating Clinical Trials in Parkinson Disease (PD) initiative (EJS ACT-PD) aims to accelerate the identification of disease modifying treatment for…Predictors of short-term anxiety outcome after subthalamic stimulation in Parkinson’s Disease
Objective: To identify clinical predictors of the effect of subthalamic nucleus deep brain stimulation (STN-DBS) on anxiety in Parkinson’s Disease (PD). Background: STN-DBS is a…Assessment of cognitive functions and gait in PD and ET patients with pharmacoresistant tremor treated with Gamma Knife thalamotomy.
Objective: The aim of our study was to assess the impact of unilateral Gamma Knife thalamotomy on gait and balance and well as psychological functioning…BBP-671, AN INVESTIGATIONAL MODULATOR OF PANTOTHENATE KINASES, DEMONSTRATES PROOF OF CONCEPT IN A PKAN MOUSE MODEL AND TARGET ENGAGEMENT IN HUMANS
Objective: Efficacy of BBP-671 as a potential therapy for pantothenate kinase-associated neurodegeneration (PKAN) was evaluated in a PKAN mouse model. Safety, PK, and PD of…Targeted training improves touchscreen skills in Parkinson’s disease and healthy elderly
Objective: To investigate the effects of dual (DT) versus single task (ST) training of touchscreen skills in Parkinson’s disease patients (PD) and healthy elderly (HE).…Huntington’s Disease, Cognition, and Fear of Falling
Objective: Explore the relationship of cognition and patient-reported assessment on fear of falling in people with Huntington’s Disease. Background: Huntington’s Disease (HD) is a relentlessly…Ocular ping pong movement to disentangle apathy from Bradykinesia in Parkinson’s disease
Objective: To disentangle bradykinesia from apathy through analysis of ocular movements. Background: While Parkinson's disease (PD) is mainly characterized by motor symptoms such as bradykinesia,…Evaluation of ocular perfusion in Parkinson’s disease and association with clinical manifestations.
Objective: To evaluate optic nerve head and macular perfusion in subjects with Parkinson's disease (PD) and its association with clinical manifestations. Background: PD is associated…Five for the price of one- A multidirectional micro-electrode recordings for DBS Surgery
Objective: To examine the use of a multidirectional micro electrode during Deep Brain Stimulation (DBS) surgery for Parkinson's Disease (PD) in 9 patients. Background: Micro-Electrode…Validation of the English version of the Parkinson Anxiety Scale in the Canadian population: Interim results
Objective: To validate the use of the English version of the PAS in Parkinson’s disease (PD) patients in Canada. Background: The PAS, originally developed to…
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