The anti-alpha-synuclein antibody Lu AF82422 binds to pathological alpha-synuclein species from human brains and inhibits seeded alpha-synuclein aggregation
Objective: Lu AF82422 is a human IgG1 monoclonal antibody that binds all known forms of alpha-synuclein (aSyn), including monomeric, aggregated and truncated. Data are presented…Noninvasive focal delivery of Adeno Associated Vectors (AAV) with magnetic resonance-guided focused ultrasound in non-human primates
Objective: Focal brain delivery of gene therapy in non-human primates is a major step towards the translation of this technology for use in humans. We…Cannabinoids for painful dystonia in corticobasal syndrome: a report of three patients
Objective: We aimed to assess the efficacy of cannabinoids in painful dystonia of corticobasal syndrome (CBS) patients Background: The clinical phenotype of CBS includes limb…Network Fingerprint of Stimulation-Induced Speech Impairment in Parkinson’s Disease
Objective: To explore structural network correlates of stimulation-induced dysarthria (SID) in patients with Parkinson’s Disease (PD) chronically treated with deep brain stimulation (DBS) of the…Hemichorea-hemiballismus following treatment of Intracranial tuberculomas and tuberculous meningitis
Objective: To present a case of right-sided hemichorea-hemiballismus that occurred following treatment of intracranial tuberculomas and tuberculous meningitis Background: A 56-year-old lady presented in the…Impact of Th17 pathway-related immuno-inflammatory cytokines in the risk and severity of Parkinson’s Disease.
Objective: To delineate the impact of T helper 17 (Th17) pathway-related cytokines in the risk, severity and psychopathology of patients with Parkinson’s Disease (PD). Background:…Clinical and Imaging features of Hyperkinetic Movement Disorders related with Stroke
Objective: To describe the characteristics of hyperkinetic movement disorders in patients with stroke. Background: Movement disorders (MD) related to cerebrovascular disease represent 22% of all…Intermuscular coherence as a biomarker of subthalamic nucleus deep brain stimulation efficacy in Parkinson’s disease
Objective: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established treatment in advanced Parkinson’s disease (PD). However, the clinical outcome after STN-DBS is…Deep brain stimulation of the subthalamic nucleus under general vs local anesthesia
Objective: The aim of the study was to compare outcomes of the deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson’s…Clinical and genetic characterization of two Portuguese families with spinocerebellar ataxia 48
Objective: Genetic and phenotypic characterization of six patients from two families, with pathogenic variants on the STUB1 gene. Background: Biallelic pathogenic variants on the STUB1…
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