The Vall d’Hebron Initiative for Parkinson (VHIP) cohort: a prospective, longitudinal and observational study enrolling de novo Parkinson’s disease (PD) patients and carriers of PD-linked mutations for biomarker and pathophysiology studies
Objective: To describe the study protocol of the Vall d’Hebron Initiative for Parkinson (VHIP) cohort, a prospective, longitudinal and observational cohort study aimed at deeply…Beyond the subthalamic nucleus: tractography patterns of Magnetic Resonance-guided Focused Ultrasound subthalamotomy
Objective: To identify subthalamic clusters that predict maximum improvement in bradykinesia, rigidity and tremor. To map-out the cortical fingerprint, which predict maximum efficacy. Background: Subthalamotomy…A novel alpha-synuclein gene (SNCA) missense variant in an Austrian familiy with atypical neuropathological features
Objective: To offer clinical, genetic and neuropathological information in a novel alpha-synuclein gene (SNCA) missense variant to further our understanding of synucleinopathies. Background: Around 5–10% of…Validation of a wireless Home-Based Sleep Laboratory for assessment of sleep-related disorders in Parkinson’s disease
Objective: To examine the validity of a new wireless wearable system which measures EEG, EOG and sEMG for the assessment of sleep and sleep related…Does needle size matter in botulinum toxin injection? A crossover randomised controlled trial of microneedle in patients with hemifacial spasm
Objective: The aim of this study was to compare the severity of pain and bruises between a microneedle (34-G) and standard needle (30-G) in patients…What research participants want to know: Feedback from participants in an observational study of Parkinson’s disease
Objective: To compare participant feedback regarding clinical assessments, patient-reported outcomes (PROs), and digital technologies provided in individual research reports in an observational study of Parkinson’s…The anti-alpha-synuclein antibody Lu AF82422 binds to pathological alpha-synuclein species from human brains and inhibits seeded alpha-synuclein aggregation
Objective: Lu AF82422 is a human IgG1 monoclonal antibody that binds all known forms of alpha-synuclein (aSyn), including monomeric, aggregated and truncated. Data are presented…Noninvasive focal delivery of Adeno Associated Vectors (AAV) with magnetic resonance-guided focused ultrasound in non-human primates
Objective: Focal brain delivery of gene therapy in non-human primates is a major step towards the translation of this technology for use in humans. We…Cannabinoids for painful dystonia in corticobasal syndrome: a report of three patients
Objective: We aimed to assess the efficacy of cannabinoids in painful dystonia of corticobasal syndrome (CBS) patients Background: The clinical phenotype of CBS includes limb…Network Fingerprint of Stimulation-Induced Speech Impairment in Parkinson’s Disease
Objective: To explore structural network correlates of stimulation-induced dysarthria (SID) in patients with Parkinson’s Disease (PD) chronically treated with deep brain stimulation (DBS) of the…
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