DBS Experience In A Pediatric Neurowilson Case
Objective: I have chosen this case to demonstrate an atypical presentation of Neuro-Wilson disease without a prominent hepatic involvement. I have also aimed to call…Bullous skin lesions following introduction of safinamide in a woman with Parkinson’s disease
Objective: To present the case of a woman with Parkinson’s disease (PD) who developed pemphigoid-like skin lesions after being started on safinamide therapy. Background: Safinamide…Cognitive and Functional Trajectories in Prediagnostic Parkinson’s Disease
Objective: To describe prediagnostic cognitive and functional trajectories in Parkinson’s Disease (PD). Background: Cognitive and functional decline is typically considered a late manifestation of PD.…Blaming neuromelanin for Parkinson’s disease: time-dependent tyrosinase overexpression drives endogenous synucleinopathy in non-human primates
Objective: Development and characterization of a novel non-human primate model of Parkinson’s disease based on the AAV-mediated forced expression of human tyrosinase Background: Although neuromelanin…Quantity detection of Substantia nigra hyperechogenicity based on digital image analysis for diagnosing Parkinson’s disease
Objective: We aimed to apply digital analysis to quantify hyperechogenicity of Substantia nigra, and explore its clinical value for the diagnosis of PD. Background: Increased…Multimodal MRI assessment of the substantia nigra in premotor and motor stages of parkinsonism
Objective: To investigate substantia nigra (SN) MRI abnormalities through Neuromelanin (NM) and diffusion MRI (dMRI) with Neurite Orientation Dispersion and Density Index (NODDI) in the…Cross-cultural validation of the Cebuano version of a screening questionnaire for Parkinson’s Disease
Objective: To determine the validity of the Cebuano version of a PD screening questionnaire Background: In the Philippines, actual prevalence of Parkinson’s Disease (PD) is…Selection of clinical doses for SBT101, an AAV9-hABCD1 vector for the treatment of adrenomyeloneuropathy
Objective: To inform selection of doses of SBT101 for a first-in-human clinical study. SBT101 is an adeno-associated virus serotype 9 (AAV9)-based gene therapy candidate intended…Functional validation of a mitochondria-specific polygenic risk score in patient-based models for stratification of idiopathic Parkinson’s disease
Objective: The overall objective of this project is to gain essential knowledge on the contribution of genetic variability in nuclear-encoded mitochondrial proteins to idiopathic Parkinson’s…Biomarker based on natural language processing methods to detect the stages of Parkinson’s disease through electroencephalography
Objective: Stage classification of Parkinson's Disease (PD) through Electroencephalograms (EEGs) using Natural Language Processing (NLP) techniques. Background: PD is a neurodegenerative disease mainly characterized by…
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