Synaptic Zn2+ Contribution to Parkinson’s Disease Pathophysiology: Pharmacological & Genetic Studies in Preclinical Mouse Models
Objective: The potential involvement of synaptic Zn2+ in development of Parkinson’s disease (PD) motor symptoms and dopaminergic neurodegeneration was investigated. Background: The progressive degeneration of…No evidence for the impact of SNCA rs356219 on Parkinson’s disease progression
Objective: To replicate findings from previous studies reporting an association between the α-synuclein (SNCA) rs356219 genetic variant and progression to key outcomes in Parkinson’s disease…The START Study: A Phase 4 Study on the Real-World Utilization of Deutetrabenazine Initiated by a 4-Week Patient Titration Kit
Objective: To assess the real-world utilization of deutetrabenazine (DTBZ) for the treatment of tardive dyskinesia (TD) or chorea associated with Huntington disease (HD) initiated by…Cortico-cortical connectivity is normalised by levodopa in tremor-dominant Parkinson’s disease
Objective: The aim of this study was to examine whether connectivity between the supplementary motor area and primary motor cortex (SMA-M1) is implicated in Parkinson’s…Ping Pong as a sport-based intervention to increase physical activity in people with Parkinson’s Disease
Objective: The aim of the study was to assess participant’s experiences, satisfaction, and safety of a sport-based intervention (Ping pong combined with PD-specific exercise). Background:…The East London Parkinson Disease Project – engaging a diverse population in research
Objective: The objective of this study was to engage a diverse group of people with Parkinson disease (PwP) from East London and build a research…Subthalamic beta bursts reflect the continuous stochastic fluctuations of ongoing oscillations in Parkinson’s disease
Objective: To test whether subthalamic beta bursts in Parkinson’s disease reflect the continuous stochastic fluctuations of an oscillatory random process. Background: Subthalamic beta oscillations in…Relationship between cardiovascular autonomic failure and cognitive performance in the α-synucleinopathies: preliminary cross-sectional analysis of the NHSS registry
Objective: To compare cognitive performances of patients with α-synucleinopathies with or without cardiovascular dysautonomia. Background: Cardiovascular dysautonomia is a disabling non-motor feature of the α-synucleinopathies and may…Awake versus Asleep Deep Brain Stimulation Lead Placement: Real-World Outcomes with Directional DBS Systems
Objective: In this report, real-world outcomes derived from Parkinson's disease (PD) patients using Deep Brain Stimulation (DBS) Systems who were implanted either awake or asleep…Tremor as a Hallmark of Neurodegeneration and Mercury Intoxication
Objective: The aim of our study was to evaluate a computerized method for assessing tremor in neurodegenerative diseases and toxic effects of mercury, taking into…
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