Longitudinal white matter microstructural changes in the prodromal phase of PD: A 2 year prospective study
Objective: To prospectively investigate white matter (WM) alterations in non-manifesting carriers (NMCs) of Parkinson's disease (PD)-related mutations, and its association with likelihood ratio (LR) scores.…SCFAs participate in the pathogenesis of Parkinson’s disease by regulating NLRP3 inflammasomes activation
Objective: To explore the role and related mechanism of gut microbiota metabolites short-chain fatty acids(SCFAs) in the pathogenesis of Parkinson's disease(PD). Background: Growing research have…Gait abnormalities relate to increased extracellular water in the substantia nigra in Parkinson’s disease patients
Objective: The aim of this study was to investigate the role of substantia nigra microstructural integrity in parkinsonian gait impairments. Background: Gait impairments are common…Nicotine and influences on hyperkinetic movement disorders
Objective: We describe hyperkinetic movement disorders with a variable response to smoking and nicotine and review clinical and pre-clinical evidence regarding the role of smoking,…The Hidden Disease Burden and Treatment Experience of Patients with Essential Tremor: A Retrospective US Claims Analysis
Objective: To describe the attributes of patients with essential tremor (ET), associated comorbidities, and ET treatments using a US claims database. Background: ET is estimated…Striatal Blood brain barrier opening in Parkinson´s disease
Objective: To test safety and feasibility of repeated low-intensity focused ultrasound (FUS) blood brain barrier opening (BBB) in the striatum of Parkinson’s disease (PD) patients.…Validating a virtual Timed Up and Go (vTUG) test in Parkinson’s Disease.
Objective: To validate the vTUG as a means of remotely monitoring patient gait and balance in the home. Background: The current regulatory gold standard for…Scaling the Roche Digital Health Technology Platform to Assess Disease Severity and Progression in Individuals with Parkinson’s Disease
Objective: Here we present the development of a novel platform to deliver the Roche Parkinson’s Disease (PD) Mobile Application to researchers to actively measure motor…Long-term non-motor and motor outcome after subthalamic stimulation in Parkinson’s disease
Objective: The primary objective of this study was to document the evolution of independence in activities of daily living in people with Parkinson’s disease treated…Very long time persistent hyperCKemia as the first manifestation of McLeod syndrome
Objective: To present a case of McLeod syndrome (MLS) with isolated muscle involvement for many years, which developed late-onset chorea leading to disease diagnosis. Background:…
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