Amantadine Delayed Release/Extended Release Capsules Reduce the Proportion of the Day Spent in “BAD” Time (ON with Troublesome Dyskinesia or OFF): Analysis of Phase 3 Trial Data
Objective: To evaluate the effect of treatment with amantadine delayed release/extended release (AMT DR/ER) vs. placebo on the proportion of the waking day spent in…A One-year follow-up study of effects of voltage/frequency Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) adjustments on speech intelligibility in Parkinson’s Disease (PD)
Objective: To assess the relationship between along-1-year stimulation voltage(V)/frequency(F) adjustments and speech intelligibility (SI) in PD patients treated with STN-DBS. Background: Low V/F stimulation improves…Continuous circadian intracerebroventricular administration of anaerobically preserved dopamine greatly reduces severe L-dopa-related complications in Parkinson’s disease
Objective: We aim to demonstrate the safety and efficacy of continuous circadian intracerebroventricular (i.c.v.) administration of anaerobic-dopamine (A-dopamine) to reduce the L-dopa-related complications (LDRC) in…Association of accelerometer-derived sleep and idiopathic dystonia: A UK Biobank cohort study
Objective: To assess the rate and nature of sleep disturbances in dystonia, and to examine the extent to which disturbance to sleep is associated with…The overexpression of a-SYN leads to a differential process of mitophagy in neurons and atrocytes
Objective: To determine the role of the different mitophagy pathways involved in PD, a key question that is still unresolved. We will investigate whether a-synuclein…Gray matter volume of proposed brain-first and body-first Parkinson’s disease subtypes
Objective: The aim of this study was to test if markers of the brain-first Parkinson’s disease (PD) subtype are associated with a greater or more…ER Visits and Hospitalizations Among Patients Treated with Pimavanserin or Other-AAPs for Parkinson’s Disease Psychosis: Analysis of Medicare beneficiaries
Objective: To examine health resource utilization (HRU) outcomes among PDP patients treated with PIMA vs. other AAPs. Background: Real-world analysis demonstrating pimavanserin (PIMA) benefits, the…The association of CSF sTREM2 with cognitive decline and its dynamic change in Parkinson’s disease: Analysis of the PPMI Cohort
Objective: This study aims to investigate the baseline and longitudinal changes of soluble fragments of triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal…Clinical and Genetic spectrum of a series of congenital ataxias patients.
Objective: To describe the clinical and molecular findings of a well-defined group of 11 congenital ataxia patients from 12 different families assessed in an adult…Preliminary estimates of the effects of deep brain stimulation on gait kinematics in Parkinson disease and essential tremor.
Objective: To determine the change in gait parameters following deep brain stimulation (DBS) in Parkinson disease (PD) and essential tremor (ET). Background: DBS is an…
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