Exosomes from human dental pulp stem cells as a cell-free drug delivery vehicle in vitro and in vivo chronic PD rat model through the intranasal route targeting efficacy & bio-distribution.
Objective: To evaluate the drug encasement in human dental pulp stem cell derived exosomes and its delivery in vitro in single cell level using fluorescence…Collective expert perspectives on the use of safinamide as adjunctive therapy for Parkinson’s disease in Japan: Online-based Delphi approach
Objective: To summarize opinions on the optimal patient profile and methods of using safinamide in common clinical scenarios, Japanese movement disorder specialists with expertise in…Presynaptic dopamine compartmentalization defects initiate auxilin-mediated parkinsonism
Objective: To evaluate the pathogenic mechanisms for auxilin-mediated Parkinson’s disease (PD). Background: Auxilin participates in uncoating of clathrin-coated vesicles (CCVs), thereby facilitating synaptic vesicle (SV)…Glial neurotrophic factor as an early diagnostic marker in Parkinson’s disease
Objective: To study the level of glial neurotrophic disease in blood plasma in patients with Parkinson's disease (PD) Background: Glial neutrophic factor (GDNF) is a…Juvenile Huntington’s Disease in Tunisia: Clinical Diversity and Literature review
Objective: We conducted the first JHD clinical and molecular features in Tunisia and North Africa, contributing to better understanding the diverse manifestation of the disease…Dopaminergic Denervation as Predictors of Axial Dysfunction in Parkinson’s Disease
Objective: We aimed to assess the usefulness of dopamine binding scores as predictors of walking and balance problems and freezing of gait (FoG) in PD.…Discrepancies in postural stability outcomes measured by computerized dynamic posturography and functional balance assessments in Parkinson’s Disease
Objective: To determine ideal assessment for detecting exercise-induced differences in postural stability of individuals with early-stage Parkinson’s Disease (PD). Background: Postural instability (PI) is a…Drivers of burden over time in caregivers of patients with Parkinson’s disease and related disorders: Findings from a community-based clinical trial of outpatient palliative care
Objective: To identify predictors of accelerated caregiver burden in patient-caregiver dyads of people with Parkinson’s disease and related disorders (PDRD). Background: PDRD are characterized by…May apomorphine be helpful for the axial symptoms of Parkinson’s Disease?
Objective: To assess the effect of continuous subcutaneous infusion of apomorphine on axial symptoms of Parkinson Disease. Background: Axial symptoms of Parkinson’s Disease may be…Adult-onset Alexander’s disease – New causal mutation in GFAP gene
Objective: In the present study we describe a new mutation (p.L58P) in the GFAP gene and its functional consequences causing a phenotype with adult-onset Alexander’s…
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