High Intensity Interval Training for people with Parkinson’s disease: individual response patterns of (non-)motor symptoms and blood-based biomarkers – a crossover single-case experimental design
Objective: To quantify individual response patterns of motor symptoms to alternating exercise modalities, along non-motor functioning and blood biomarkers of neuroplasticity and neurodegeneration. Background: Physical…Safety of foslevodopa/foscarbidopa during optimization and maintenance treatment: Post hoc analysis of a phase 3, single-arm trial
Objective: Evaluate the frequency of adverse events over time with foslevodopa/foscarbidopa (LDP/CDP) in patients with advanced Parkinson’s disease (PD) in a phase 3, open-label safety…Reproductive life factors and sex hormones in post-menopausal female patients with Parkinson’s Disease
Objective: To deepen into sex-dependent mechanisms of Parkinson’s disease (PD) by analyzing the relationships between reproductive life factors, sex hormones, clinical features, and CSF biomarkers…The epigenetic association of Parkinson’s disease risk gene- GPNMB rs199347 with drinking
Objective: This paper examines the epigenetic association of rs199347 polymorphism variants of the GPNMB with drinking and DNA methylation changes. Background: Neuroinflammatory response induced by alcohol…Unsupervised physical capacity testing at home: a systematic review
Objective: Systematically review home-based physical capacity tests and their clinimetric properties in different patient populations with a chronic disease. Background: Physical capacity is a predictor…Does hyposmia induce apathy in early Parkinson’s disease? Lessons from structural brain connectivity
Objective: To study changes in microstructural integrity of white matter tracts associated with apathy in patients with early Parkinson’s disease (PD) and hyposmia Background: Smells…24(S)-Hydroxycholesterol and cognition in Huntington’s disease: results from two large patient cohorts (TRACK-HD and ENROLL-HD)
Objective: To investigate correlations between plasma levels of 24(S)-Hydroxycholesterol (24[S]-HC) and cognitive performance in participants with Huntington’s disease (HD) using data from ENROLL-HD. Background: HD…Impairment of SHH signaling in PD LRRK2 I1371V iPSC derived floor plate cells contribute to ontogenic origin of lower dopaminergic-neuron yield
Objective: To estimate SHH responsiveness & signaling of Floor Plate Cells (FPCs) derived from LRRK2 I1371V PD patient-iPSCs along with its link with LRRK2 I1371V…Nutritional traits in the prodromal phase on Parkinson’s disease in community-dwelling older adults in Japan
Objective: The objects of this study is to clarify the relationship between nutritional traits and the prodromal phase of PD in the community-dwelling older adults.…Effect of Recognition of Vertical Posture on Forward Bending Posture in Patients with Parkinson’s Disease: A Multicenter Observational Study
Objective: The mechanisms of postural abnormalities in Parkinson’s disease are diverse but often intractable, and there are no established measures to prevent early-stage progression. Background:…
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