VALIdation of models for assessing eligibility for referral for Device-Aided Treatment in Parkinson’s disease (VALIDATE)
Objective: To externally validate the Dutch Device-Aided Therapy Screening tool (D-DATS) and to compare it with the 5-2-1 criteria. Background: Timely identification of patients with…Mosaic divergent repeat interruptions in X-linked dystonia-parkinsonism: stability over generations and time
Objective: This study aims to investigate the stability of Mosaic Divergent Repeat Interruptions affecting motif Length and Sequence (mDRILS) frequencies and repeat length across generations…A novel, population-specific PINK1 p.F385S loss of function mutation in an Indian family with Parkinson’s disease
Objective: To understand the molecular function of a novel missense PINK1 variant identified in an Indian family with Parkinson’s disease (PD). Background: The molecular understanding…Sympathetic tone abnormalities in subjects at risk for Parkinson’s Disease without evidence of nigrostriatal neurodegeneration: a multimodal biomarker study
Objective: To study autonomic dysfunction in subjects with idiopathic REM sleep behavior disorder (iRBD) and at least one pre-motor symptom of Parkinson's disease (PD). Background:…Testing gene-environment interaction in Parkinson’s disease (PD) using whole-genome sequencing of pesticide-exposed cohorts.
Objective: To identify interactions of specific pesticides with genetic loci to find causal variants for PD using gene burden analysis (BA). Background: Pesticide exposure is…Oculomotor parameters measured during free viewing of video differentiate Parkinson’s disease from progressive supranuclear palsy
Objective: Characterize oculomotor phenotypes comprised of saccade, pupil, and blink behaviour for progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) with differing degrees of cognitive…Development and Evaluation of a Digital Resource Library for Arkansans with Parkinson Disease and Their Caregivers
Objective: To develop and evaluate impact of a Digital Resource Library (DRL) to address unmet needs for disease state education of People with PD (PwP)…Novel application of the Timed Up and Go Scale as a reliable tool to measure functional improvement and fall prevention after inpatient Parkinson’s Disease specific rehabilitation for advanced stages of PD
Objective: To determine whether the “Timed Up and Go” (TUG) scale can be effectively utilized in patients with advanced Parkinson’s disease (PD) as an outcome…Correlations between bradykinesia and acoustic speech variables in advanced Parkinson’s Disease
Objective: To find the presence of possible correlations between upper extremity bradykinesia and speech variables in different medication conditions in a cohort of advanced Parkinson’s…A multiple-dose thorough QT study to evaluate the effect of ampreloxetine on cardiac repolarization in healthy subjects
Objective: To characterize the effect of therapeutic and supratherapeutic doses of ampreloxetine on cardiac repolarization in healthy subjects. Background: Ampreloxetine is a potent NE reuptake…
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