Combined effect of polygenic background and GBA Pathogenic variants in Parkinson’s disease risk
Objective: We aimed to investigate whether polygenic background affects the penetrance of Parkinson’s disease (PD) among carriers of heterozygous pathogenic variants (PV) in GBA. Background: Several rare homozygous mutations within…Parkinson’s disease and Charcot-Marie-Tooth type 2: coincidental or causal?
Objective: To report a patient with Charcot-Marie-Tooth (CMT) type 2N (CMT2N) due to AARS gene mutation who developed early-onset Parkinson’s disease (PD). Background: Aminoacyl tRNA…Chinese medicine pattern diagnostic criteria in clinical and epidemiological studies of Parkinson’s disease: a systematic review
Objective: To summarize the diagnostic criteria of Chinese medicine patterns (CMPs) adopted by clinical and epidemiological studies of Parkinson’s disease (PD). Background: One major reason…Clozapine Therapy for Parkinson’s Disease Psychosis: A 21-Year Service Analysis
Objective: To review the demographic aspects, safety, and efficacy of Clozapine treatment for Parkinson’s Disease Psychosis (PDP) in a large patient cohort. Background: The impact…Case report- Cavernoma involving substantia nigra and nigrostriatal pathway as a rare cause of secondary parkinsonism with a 3 year follow up
Objective: To describe a case report of a rare cause of Parkinsonism Background: Vascular malformations such as cerebral cavernomas are known to predispose to haemorrhagic…Bilateral staged MRI-guided focused ultrasound subthalamotomy for Parkinson’s disease
Objective: To assess the feasibility and safety of bilateral staged focused ultrasound subthalamotomy(FUS-STN) for Parkinson's disease(PD). Background: Unilateral FUS-STN for PD improves contralateral motor features…Vaccination from Covid-19 in people with Parkinson`s disease
Objective: To assess safety and efficacy of COVID-19 vaccines against SARS-CoV-2 in people with Parkinson’s disease. Background: Different forms of vaccines have been developed to…Using mediation analysis to account for the effect of Parkinson’s Disease medications on disease progression
Objective: To explore the use of mediation analysis to incorporate L-dopa equivalent daily dose (LEDD) for disease progression of Parkinson’s Disease (PD) in a simulation…MRgFUS thalamotomy in dystonic and essential tremor: a prospective study with one year follow up
Objective: The primary objective of this study was to evaluate the effectiveness of MRgFUS thalamotomy in patients with Dystonic Tremor (DT) compared with patients with…Directional deep brain stimulation therapy in the long term
Objective: To describe our long-term clinical experience with directional deep brain stimulation (d-DBS) in patients with advanced Parkinson’s disease (PD) who have been implanted with…
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