Identifying prodromal NMS in a population-based recruitment strategy: Kassel data of Healthy Brain Ageing
Objective: To identify subjects with NMS for recruitment of a cohort at risk for prodromal PD Background: Neurodegeneration in PD starts years before the development…Localisation of distinct brain networks in premanifest and manifest Huntington’s disease
Objective: To map the brain networks underlying Huntington’s Disease (HD), testing whether there are distinct networks involved in premanifest and manifest disease stages. Background: HD…Clinical and genetic characteristics of a cohort of 20 patients with confirmed biallelic pathogenic SPG7 mutations from the North West of England
Objective: To identify the prevalence and phenotype of patients with biallelic pathogenic SPG7 mutations Background: Spastic Paraplegia Type 7 (SPG7) is an autosomal recessive disorder…restless leg syndrome in parkinson’s disease patients: prevalence and correlates with sleep parameters
Objective: The aim of the present study is to explore the clinical significance and frequency of restless leg syndrome (RLS) in a sample of patients…Non-tremor motor dysfunction in Parkinson’s disease is associated with decreased [18F]FMPEP-d2 binding
Objective: To explore the relationship between cannabinoid receptor type 1 (CB1) availability and motor symptoms in Parkinson’s disease (PD) with [18F]FMPEP-d2 positron emission tomography (PET).…Longitudinal assessment of evolution and plasma biomarkers for depression and anxiety in Parkinson’s disease
Objective: We aimed to investigatethe evolution of depression and anxietyin a large Parkinson's disease (PD) cohort and explore the related plasma biomarkers. Background: Depression and anxietyare common non-motor…Early-phase 18F-FP-CIT PET images: a promising imaging biomarker for predicting early dementia conversion in Parkinson’s disease
Objective: This study aims to investigate whether early-phase 18F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (18F-FP-CIT) positron emission tomography (PET) images (i.e., images acquired within the first 10 min after…Novelty Seeking: A Narrative Review
Objective: To explore novelty seeking (NS) as a construct, in both its adaptive and maladaptive roles, in order to provide insight into the cognitive and…Evaluation of possible pre-motor symptoms of Parkinson’s disease in a GBA-mutation positive cohort, as well as Gaucher disease patients.
Objective: To clinically evaluate a cohort of healthy glucocerebrosidase (GBA) mutation carriers in search of early biomarkers for neurodegeneration that may be prodromal features of…Atypical Manifestations of Subacute Sclerosing Panencephalitis (SSPE): A Case Series from India
Objective: To report unusual manifestations Subacute Sclerosing Panencephalitis. Background: Subacute Sclerosing Panencephalitis (SSPE) is a slow viral infection caused by measles virus resulting in progressive…
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