Development of potent, orally bioavailable, and highly selective LRRK2 PROTAC® degrader molecules as potential disease modifying therapeutics for Parkinson’s disease
Objective: Report on the pharmacological characteristics of small molecule PROteolysis TArgeting Chimera (PROTAC) molecules designed to induce degradation of leucine rich repeat kinase 2 (LRRK2)…Differential effect of MAPT haplotype on survival in CBD and PSP-SCB phenotype
Objective: Evaluate the association of MAPT haplotype with the risk of PSP-CBS and CBD severity of tau pathology by studying the survival rate of both…Measures of trancranial magnetic evoked potentials for prediction of response to ventriculoparitoneal shunt In normal pressure hydrocephalus
Objective: Assess the utility of an EEG-TMS-based evaluation for prediction of response to ventriculoperitoneal shunt (VPS) in normal pressure hydrocephalus (NPH). Background: VPS is the…Unveiling the role of subthalamic nucleus stimulation on freezing of gait in Parkinson disease using wearable sensors
Objective: Objectives: To determine whether Deep Brain Stimulation on the Subthalamic nucleus (STN-DBS) is responsible for post-surgery de novo On-State Freezing-of-Gait (FOG) in PD patients, and…self-compassion, trait worry and sleep in parkinson’s disease (PD) patients
Objective: to evaluate possible interactions between measures ofself-compassion, trait worry and sleep in Parkinson’s Disease (PD) patients. Background: PD patients often experience states of persistent…DaT Scan Positive Parkinson’s Disease in a Patient with Anti-MuSK Positive Myasthenia Gravis
Objective: We present a unique clinical case of antibody positive Muscle Specific Kinase (MuSK) Myasthenia Gravis and DaT scan positive Parkinson's Disease to highlight the…Sleep-Wake Dependent Modulation in Pallidal Beta and High-Frequency Oscillations in Parkinson’s Disease
Objective: To characterize the dynamics of oscillatory activity in the globus pallidus internus (GPi) across the sleep-wake cycle in people with Parkinson’s disease (PD) with…An atypical presentation of Multiple System Atrophy (MSA)
Objective: To discuss the etiological differential diagnosis of the clinical phenotype characterized by myoclonus and parkinsonism. Background: The presence of myoclonus is increasingly recognized as…Chronic sensorimotor cortex sensing using permanently implanted subgaleal leads in a patient receiving deep brain stimulation for Parkinson’s disease
Objective: Assess the feasibility of chronic subgaleal cortical sensing using two distinct recording leads. Background: Pathological oscillatory activity in cortico-basal ganglia (BG) circuits is implicated…Palliative Care in Parkinson: a family caregiver’s view. A PD-PAL Consortium initiative.
Objective: We aim to identify clinical indicators and markers for timely referral, access, and need of PC in our PwP community, from the viewpoint of…
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