Actigraphy wear compliance across CNS disorders
Objective: Examine actigraphy wear compliance in 5 neurological-disorders clinical trials using an ActiGraph GT9X Link with additional compliance features Background: Wrist worn biometric devices are…Gene rearrangement as the cause of hereditary Hypomyelinating Leukodyistrophy disease type 5 (HLD5)
Objective: To define the clinical, neurophysiological, neuroimaging and pathological findings from a patient carrying a FAM126A homozygous exon 3-7 deletion. Background: Hypomyelinating leukodystrophies constitute a…Manifestations of aging and Parkinson’s Disease in low-frequency fluctuations of postural sway velocity
Objective: To distinguish the effects of aging and Parkinson's disease on balance control. Background: Many balance control measures are derived from spontaneous fluctuations of the center…Hemidystonia of cerebellar origin
Objective: To report the case of a patient developing hemidystonia in the course of cerebellar hemorrhage. Background: About 1-4% of strokes may include movement disorders,…Cholinergic subtyping in Parkinson disease: differential 2-year interval changes
Objective: To investigate 2-yr interval change in cholinergic transporters in biology-based cholinergic subgroups using serial VAChT [18F]FEOBV brain PET in Parkinson’s disease (PD). Background: Current…Practice and outcome variation across Parkinson’s Foundation Centers of Excellence
Objective: To identify center-level variations in Parkinson’s disease (PD) treatment practices and outcomes, and the relationship between treatment and outcomes to inform best practices Background:…Acute-onset parkinsonism secondary to bilateral extrapontine myelinolysis of the basal ganglia: case report
Objective: Although rapid osmolar correction, mainly in the setting of hyponatremia is the main risk factor of osmotic demyelination syndrome, the pathogenesis of the syndrome…Efficacy and safety of safinamide in PD patients over 70 years vs. under 70 years old;
Objective: To search for any differences between efficacy and safety of safinamide in PD patients over 70 years vs. under 70 years old. Background: Safinamide…Cognitive overlap between Parkinson disease (PD) and Alzheimer’s disease (AD) is associated with plasma biomarkers and their impact on regional cortical thickness (CT): An ONDRI Study
Objective: To investigate cognitive performance across the Parkinson-Alzheimer’s spectrum and its association with plasma biomarkers and regional CT. Background: While PD and AD are neurodegenerative…Verbal Fluency Changes After Unilateral STN Deep Brain Stimulation in Parkinson’s Disease: A Connectomics-Based Approach
Objective: To investigate neural circuitry associated with verbal fluency changes after STN-DBS in Parkinson’s disease. Background: Despite its substantial motor benefits, subtle cognitive changes can…
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