Characterization of the pathogenic α-Synuclein variant p.V15A in Parkinson´s disease
Objective: To investigate functional alterations of the p.V15A variant in alpha-Synuclein (α-Syn) in Parkinson's disease (PD). Background: PD is marked by the loss of dopaminergic…Discriminative properties and sensitivity to change of three cognitive assessment instruments in Huntington’s disease
Objective: We addressed and compared the discriminative properties of different cognitive instruments, and we determined the sensitivity to change of the proposed assessments in the…SYNCHRONIZE: Real-world retrospective safety analysis in patients treated with onabotulinumtoxinA for more than one therapeutic indication
Objective: Report real-world safety of onabotulinumtoxinA used concomitantly for multiple therapeutic indications. Background: Therapeutic onabotulinumtoxinA is approved in the US for 12 indications, some of…Neuroprotective effects of oral consumption of Bifidobacterium lactis and Lactobacillus acidophilus probiotics on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropytide-induced Parkinson’s Disease mouse model
Objective: To explore the effects of probiotics strains Bifidobacterium animalis subsp. lactis (B.lactis) and Lactobacillus acidophilus (L.acidophilus) on the inflammation of gut-brain axis and degeneration…Response of extraocular movements in parkinson’s disease to levodopa: an electrooculographic perspective
Objective: To determine the response of latencies and amplitudes of saccadic movements to Levodopa in idiopathic Parkinson’s Disease. Background: Neurodegeneration in Parkinson’s Disease (PD) increases…Ventral tegmental deep brain stimulation does not influence risk-taking behaviour in a standard gambling task
Objective: We here used a standard gambling task that involved risky decision-making. This permitted us to measure the effects of ventral tegmental area (VTA) deep…Hemichorea syndrome secondary to diabetic striatopathy with contralateral drug-induced parkinsonism: a different threshold for drug induced movement disorders?
Objective: Localized structural damages could impair the threshold of activation and/or inhibition of the nigrostriatal pathway with a mirrored effect on the healthy and pathological…Effects of Unilateral and Bilateral DBS of STN, GPi on Voice in PD Patients
Objective: To study the effects of Deep Brain Stimulation (DBS) of subthalamic nucleus (STN) and globus pallidus interna (GPi) on voice in patients with Parkinson’s…The High Prevalence of Developmental Vascular Anomalies in Parkinson’s Disease using USPIO-based MICRO MRI
Objective: To improve cerebral vascular visibility using an ultra-small super-paramagnetic iron oxide (USPIO) contrast agent and identify vascular abnormalities in patients with Parkinson’s disease (PD).…How do people with Parkinson’s disease experience self-optimization of treatment using digitally supported symptom monitoring?
Objective: The aim of this study was to investigate how people with Parkinson´s disease experience an intervention of optimizing their own medical treatment through digitally…
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