Hereditary spastic paraplegia type 4 (SPG4): an international multicenter clinical and genetic study
Objective: To describe the epidemiological, clinical, and genetic features of patients affected by hereditary spastic paraplegia (HSP) in an international cohort of affected individuals.To describe…A non-expensive bidimensional assessment can detect subtle alterations in gait performance in people in the early stages of Parkinson’s disease
Objective: To investigate the effectiveness of a two-dimensional gait assessment to identify the decline in gait performance associated with Parkinson's disease progression Background: Gait is…Prevalence of urinary symptoms and its impact on life quality in patients living with parkinson disease in a mexican population
Objective: To describe the prevalence and the impact on the quality of life in patients living with Parkinson’s disease with urinary symptoms. Background: Parkinson's disease…Extended phenotypes of autosomal recessive cerebellar ataxia type 1: learn from a novel mutation of SYNE1 gene
Objective: Mutations in the synaptic nuclear envelope protein 1 (SYNE1) gene have been reported to cause ARCA type 1 with a remarkable heterogeneity in clinical…Parkinson’s disease-specific cortical atrophy as an independent contributor to motor symptom in Parkinson’s disease
Objective: In this study, we identified specific pattern of cortical atrophy in Parkinson's disease (PD) and investigated whether PD-specific cortical atrophy contributed to motor symptom,…Clinical accuracy of Medtronic’s Percept built in longevity estimate algorithm following device exchange.
Objective: To examine the accuracy of Medtronic’s Percept built in device longevity estimate. Background: In June of 2020 Medtronic received FDA approval for its Percept…Clinical usefulness of tandem gait test for estimating gait and balance in de novo Parkinson’s disease
Objective: The purpose of this study is to objectively evaluate the gait and balance in patients with Parkinson’s disease showing abnormal tandem gait, using three-dimensional motion analysis.…Modeling Parkinson’s disease progression accounting for the effect of symptomatic treatments in the Parkinson’s Progression Markers Initiative study
Objective: To explore the natural history of Parkinson’s disease (PD) accounting for the effect of symptomatic treatments on progression by modeling the time course of…Anle138b-P1-02: A randomised, double-blinded, placebo-controlled phase 1b study to investigate safety, tolerability, pharmacokinetics and pharmacodynamics of the oligomer modulator anle138b in Parkinson´s disease
Objective: To present first-in-patient data of the oligomer modulator anle138b (TEV-56286, emrusolmin) in patients with Parkinson’s disease (PD). Background: Synucleinopathies such as PD and Multiple…Clinical characteristics of patients with dementia with Lewy bodies followed in a movement disorder clinic
Objective: To describe the clinical phenotype of the subgroup of patients with Dementia with Lewy bodies (DLB) followed in a movement disorder setting rather than…
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