Serum levels of VEGF-C and ENDGLIN in Parkinson’s disease and their clinical relevance
Objective: To evaluate the differences in serum concentrations of neurovascular unit (NVU)-related cytokines between patients with Parkinson's disease (PD) and control subjects (Ctr) and to…LRRK2 I1371V Mutation: Unraveling Pathogenic Mechanisms in Dopaminergic Neurons via Membrane Fluidity & Calcium Dysregulation using PD Patient iPSCs
Objective: To estimate pathogenicity of LRRK2 I1371V mutation in PD patient iPSC-derived DA-neurons & assess underlying disease mechanisms involving membrane fluidity, Ca2+ dysregulation, & Rab8A/Rab10…Ultrasound of Spinal Fluid Dynamics in Headache and Vertigo Patients with Central Sensitization: Novel Biomarker
Objective: This study aimed to investigate the neurophysiological responses and potential mechanisms underlying the therapeutic effects of ultrasound (US)-guided dry needling in patients presenting with…The dementia with Lewy bodies related metabolic brain pattern (DLBRP) – a multicentric validation
Objective: Dementia with Lewy bodies-related pattern (DLBRP) has been identified from the FDG PET brain imaging of DLB patients and healthy controls previously. A multicentric…Increased Brain Free Water is Associated with Regional Gene Expression in Parkinson’s Disease
Objective: In this study, we used brain free water scores and regional gene expression profiles from the Allen Human Brain Atlas transcriptomic data to investigate…Microstructural Changes in the Inferior Tuberal Hypothalamus Correlate with Daytime Sleepiness in Lewy Body Disease
Objective: Identify neuroimaging correlates of excessive daytime sleepiness in Lewy body disorders using diffusion MRI. Background: Excessive daytime sleepiness (EDS) is a common and disabling…Neurovascular Involvement in Parkinson’s Disease Cognitive Impairment: A 4D Flow Study
Objective: To investigate the cerebrovascular contribution to cognitive decline in Parkinson’s disease (PD). Background: Cognitive impairment is a major non-motor feature of PD. Accruing evidence…The 2-Minute Walking Test Predicts Aerobic Fitness, Motor Function, and Brain Health in Parkinson’s Disease
Objective: To determine the association of performance on the 2-Minute Walking Test (2MWT) with aerobic fitness, motor and cognitive function, and brain health in mild…Reduced parietal and sensorimotor cortex recruitment during complex gait in Parkinson’s disease patients with freezing of gait
Objective: To investigate cortical brain activity changes during complex gait in Parkinson’s disease (PD) patients with and without freezing of gait (FOG) using functional near…Comparative Study of Whole-Brain Functional Connectivity Patterns in Parkinson’s Disease and Essential Tremor: A Resting-State fMRI Study
Objective: Our study aimed to analyze the alterations in brain FC in subjects with tremor-dominant PD compared to ET subjects. Background: While both tremor-dominant Parkinson’s…
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