The LRRK2 I1371V mutation alters membrane dynamics and inflammatory profile of astrocytes differentiated from LRRK2-I1371V PD Patient iPSCs
Objective: To evaluate the membrane dynamics and inflammatory profile of astrocytes differentiated from LRRK2-I1371V PD iPSCs in the presence and absence of extracellular α-Synuclein. Background:…A novel single-cell reporter identifies regulators of the endogenous PINK1-Parkin mitochondrial quality control pathway
Objective: We aimed to identify genome-wide regulators of the PINK1-Parkin pathway using a novel flow cytometry reporter, endogenously tagged MFN2, as a readout of the…Discriminating alpha-synuclein strains in Parkinson’s disease
Objective: To evaluate possible differences in the biological properties of alpha-synuclein fibrils derived from different patients with Parkinson's disease. Background: Parkinson’s disease (PD) is a…Polyamine pathways: a promising frontier for biomarkers and therapeutic targets in Parkinson’s disease (PD)
Objective: To systematically modulate polyamine (PA) metabolic pathways and investigate PA biomarker findings in PD using Drosophila melanogaster over-expressing human wild-type α-synuclein gene (hSNCA). Our…Machine Learning Model Comparison for Freezing of Gait Prediction in Advanced Parkinson’s Disease Patients
Objective: This study compares the performance of machine learning classification models in predicting freezing of gait (FoG) from instrumented stand-and-walk trials in advanced Parkinson’s disease…Differentiating Progressive Supranuclear Palsy from Corticobasal Syndrome Using Cortical Diffusion MRI
Objective: To compare cortical microstructural measures in Progressive Supranuclear Palsy (PSP) and Corticobasal Syndrome (CBS) using cortical diffusion magnetic resonance imaging (MRI). Background: Differential diagnosis…Sex-Related Differences of Resting-State Brain Activity in Parkinson’s Disease
Objective: To investigate sex-related differences of resting-state functional magnetic resonance imaging (rs-fMRI) metrics in early-stage, untreated Parkinson’s disease (PD) patients. Background: Sex plays an important role in the heterogeneity of PD, but its effects…Cortical morphometry and subcortical volumetry in motor subtypes of Parkinson’s disease
Objective: This study aims to evaluate the presence of differences in cortical morphometry and subcortical volumetry in tremor dominant Parkinson’s disease (TDPD) and postural instability…the Degeneration of Locus Coeruleus and its Enhanced Causal Relationship to Neural Circuit in Parkinson’s Tremor
Objective: We aim to decode the neuroimaging features of LC in Parkinson's tremor. Background: Tremor is the primary symptom of Parkinson's disease (PD) and exhibits…From Images to Insights: Subtyping Parkinson’s Disease Using Unsupervised Learning on MRI Data
Objective: To explore the heterogeneity of Parkinson's disease (PD) using unsupervised clustering of neuroimaging data, aiming to identify distinct subtypes based on volumetric features. Background:…
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