Prospective Tractography-Guided STN DBS Targeting with Optimized vmPFC Connectivity for Apathy in PD a Case Report
Objective: Prospective tractography-guided DBS targeting of the left STN-vmPFC and primary motor pathway to improve apathy alongside motor symptoms in PD. Background: While STN DBS…Uncovering the heterogeneity of spatiotemporal trajectories of neurodegeneration in Parkinson’s disease: an early-phase 18F-FP-CIT PET study
Objective: To define the subtypes of Parkinson’s disease (PD) based on the spatiotemporal progression patterns of cerebral hypoperfusion. Background: Early-phase 18F-FP-CIT PET images, which are…Using Multi-Generational High-Risk Pedigrees to Identify Candidate Parkinson’s Disease Predisposition Genes
Objective: To identify rare genetic variants associated with increased risk of Parkinson’s disease (PD) in multi-generational, high-risk pedigrees. Background: Our current knowledge of PD genetics…Does COMT Play a Role in Parkinson’s Disease Susceptibility Across Diverse Ancestral Populations?
Objective: To investigate the relationship between COMT genetic variants and PD risk across diverse ancestries. Background: The enzyme catechol-O-methyltransferase (COMT; OMIM:116790) plays a crucial role…Interplay of GBA1 mutations and sex on determining depressive symptoms in Parkinson’s Disease
Objective: To study the interaction between GBA1 mutations, sex and other clinical factors in shaping depression outcomes in Parkinson’s Disease. Background: Depression affects 35% of…Studying the Influence of Genetic Variations on Functional Performance in Parkinson’s Disease
Objective: To evaluate whether individuals with one of the seven most common genetic variants associated with Parkinson’s Disease (PD) exhibit differences in physical function performance…Revealing Novel Genetic Contributors to Parkinson’s Disease in a Chinese Cohort: An Elaborate Examination within the CPD10KGP
Objective: This study employs next-generation sequencing (NGS) and long-read sequencing data (LRS) in Chinese AR-PD families to uncover novel genes, enhancing our genetic comprehension of PD. Background:…Efficacy and Safety of Fecal Microbiota Transplantation in the Management of Parkinson’s Disease: A Systematic Review
Objective: 1. Assess the efficacy of FMT in PD by evaluating its impact on motor and non-motor symptoms.2. Determine the safety profile of FMT in…DBS Programming in Early Simultaneous STN-GPi Implantation for Young-Onset Parkinson’s: A Mini Case Series
Objective: We aim to present our institution's experience with simultaneous dual STN-GPi implantation in Parkinson’s disease (PD) by analyzing a case series of 3 patients.…Preoperative Predictors of Post-DBS Cognitive Decline: Cardiac MIBG Imaging and Levodopa Burden as Risk Factors for Dementia in Parkinson’s Disease
Objective: To identify preoperative clinical and imaging predictors of post-deep brain stimulation (DBS) dementia in Parkinson's disease (PD) patients, focusing on multiple potential risk factors…
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