Rapid Neurologic Decline after Subthalamic Nucleus Deep Brain Stimulation in Leucine-Rich Repeat Kinase 2 Parkinson’s disease (LRRK2-PD)
Objective: To describe the clinical outcomes of two unrelated patients with LRRK2-PD who experienced rapid neurologic decline following subthalamic nucleus deep brain stimulation (STN-DBS). Background:…Identifying Differential DNA Methylation Pathways in Parkinson’s Disease and REM Sleep Behavior Disorder
Objective: To investigate differential methylation patterns of cell-free DNA (cfDNA) between Parkinson’s Disease (PD), REM Sleep Behavior Disorder (RBD), and Healthy Control (HC) groups. Background:…Gene-Caffeine Interaction in Parkinson’s Disease: A Case-Control Study of Alpha-synuclein SNPs
Objective: Investigating the interaction between genetic susceptibility and caffeine intake in modulating Parkinson’s disease (PD) risk. Background: PD arises from a complex interplay of genetic…Oculomotor Differences in PARK2 PD: a Study of Structured and Unstructured Eye Movements in an Irish Genetic Cohort
Objective: To identify and measure how eye movements differ between biallelic PARK2 carriers, carriers of a single PARK2 variant and non-carriers using structured and unstructured…Effects of conventional and adaptive deep brain stimulation on systemic oxy-Inflammation in Parkinson’s Disease
Objective: This study investigates the impact of conventional (cDBS) and adaptive deep brain stimulation (aDBS) on systemic oxidative stress (OxS) and inflammation in Parkinson’s Disease…Symptomatic Peri-Lead Oedema After Bilateral Subthalamic Nucleus Deep Brain Stimulation Surgery- Not All Cases Are Self-Limiting: A Case Series
Objective: To share 3 cases presented with seizure and encephalopathy after bilateral subthalamic nucleus deep brain stimulation surgery for Parkinson’s disease that requires removal of…Real-World USA Outcomes in Patients Implanted with DBS Systems Capable of Directionality and Multiple Independent Current Control
Objective: This on-going registry seeks to collect/analyze real-world clinical outcomes out to 2-years follow-up in levodopa-responsive Parkinson's disease (PD) patients implanted with Deep Brain Stimulation…A Retrospective, Multicenter, Harmonized Data Collection for Uncovering DBS Long-Term Axial Response
Objective: To determine pre-surgery (e.g., motor phenotype), during-surgery (e.g., electrodes' position), and post-surgery (e.g., stimulation parameters) factors predicting DBS-induced effects on axial symptoms in people…The Impact of Bilateral GPi Deep Brain Stimulation on Non-Motor Symptoms in Parkinson’s Disease
Objective: This study aimed to evaluate how bilateral Globus Pallidus internus (GPi) Deep Brain Stimulation (DBS) affects non-motor symptoms in individuals diagnosed with Parkinson’s disease…Association between corneal sensitivity with vision-related quality of life and ocular surface symptoms in Parkinson’s disease
Objective: To evaluate the association between corneal sensitivity (CS) as measured by a non-contact Brill Engines esthesiometer, vision-related quality of life and ocular surface symptoms…
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